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Efficient synthesis via azide–alkyne Huisgen [3+2] cycloaddition reaction and antifungal activity studies of novel triazoloquinolines

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Abstract

New functionalized 1,2,3-triazoloquinolines were achieved by intramolecular azide–alkyne Huisgen [3+2] cycloaddition. These derivatives were synthesized via the key Baylis–Hillman adduct under mild, neutral conditions in short duration and consistently good yield. The structures of final compounds were characterized by spectral analysis. Antifungal activities of these analogues against Trichophyton mentagrophytes, Candida albicans, and Aspergillus niger were also assayed.

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Acknowledgments

The authors are grateful to the Department of Chemistry, SRM University for providing the laboratory facilities to carry out the research work. The authors are also grateful to Dr. Suresh for his valuable suggestions.

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Authors and Affiliations

  1. Department of Chemistry, SRM University, Kattankulathur, Chennai, 603203, India

    Nagarajan Saravanan, Maruthapillai Arthanareeswari, Palanisamy Kamaraj & Bitragunta Sivakumar

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  1. Nagarajan Saravanan
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  2. Maruthapillai Arthanareeswari
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  3. Palanisamy Kamaraj
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  4. Bitragunta Sivakumar
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Correspondence to Nagarajan Saravanan.

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Saravanan, N., Arthanareeswari, M., Kamaraj, P. et al. Efficient synthesis via azide–alkyne Huisgen [3+2] cycloaddition reaction and antifungal activity studies of novel triazoloquinolines. Res Chem Intermed 41, 5379–5388 (2015). https://doi.org/10.1007/s11164-014-1638-1

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  • DOI: https://doi.org/10.1007/s11164-014-1638-1

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