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A mild and efficient method for the conversion of aldehydes into nitriles and thiols into disulfides using an ionic liquid oxidant

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Abstract

A simple, mild and high yielding method for the conversion of various aldehydes to nitriles has been developed using an ionic liquid reagent, hexamethylene bis(N-methylimidazolium) bis(dichloroiodate) (HMBMIBDCI), in combination with aqueous ammonia in CH3CN at room temperature. Moreover, the treatment of aromatic and aliphatic thiols with HMBMIBDCI resulted in the corresponding disulfides in solvent-free condition at room temperature.

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Acknowledgment

We thank the Research Council of University of Mazandaran for the partial support of this work.

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Authors and Affiliations

  1. Department of Organic Chemistry, Faculty of Chemistry, University of Mazandaran, Babolsar, Iran

    Rahman Hosseinzadeh & Mahboobe Nouzarian

  2. Department of Inorganic Chemistry, Faculty of Chemistry, University of Mazandaran, Babolsar, Iran

    Hamid Golchoubian

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  1. Rahman Hosseinzadeh
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  2. Hamid Golchoubian
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  3. Mahboobe Nouzarian
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Correspondence to Rahman Hosseinzadeh.

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Hosseinzadeh, R., Golchoubian, H. & Nouzarian, M. A mild and efficient method for the conversion of aldehydes into nitriles and thiols into disulfides using an ionic liquid oxidant. Res Chem Intermed 41, 4713–4725 (2015). https://doi.org/10.1007/s11164-014-1562-4

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