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Magnetic nanoparticles Fe3O4-supported guanidine as an efficient nanocatalyst for the synthesis of 2H-indazolo[2,1-b]phthalazine-triones under solvent-free conditions

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Abstract

Here, the application of guanidine supported on magnetic nanoparticles Fe3O4 (MNPs-guanidine) as a novel magnetically separable base nanocatalyst is described. We have investigated the application of this new catalyst for the synthesis of 2H-indazolo[2,1-b]phthalazine-trione derivatives from the three-component, one-pot condensation reaction of phthalhydrazide, cyclic 1,3-dicarbonyl, and aromatic aldehydes under solvent-free conditions. The products were obtained in short reaction times with good to high yields. The supported catalyst could be simply separated and recovered from the reaction mixture with the assistance of an external magnet and reused 18 times with little loss of activity.

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Acknowledgment

We are grateful to the University of Kurdistan Research Councils for partial support of this work.

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Authors and Affiliations

  1. Department of Chemistry, Faculty of Science, University of Kurdistan, 6617715143, Sanandaj, Iran

    Bahareh Atashkar, Amin Rostami, Hoshyar Gholami & Bahman Tahmasbi

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  1. Bahareh Atashkar
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  2. Amin Rostami
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  3. Hoshyar Gholami
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  4. Bahman Tahmasbi
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Correspondence to Amin Rostami.

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Atashkar, B., Rostami, A., Gholami, H. et al. Magnetic nanoparticles Fe3O4-supported guanidine as an efficient nanocatalyst for the synthesis of 2H-indazolo[2,1-b]phthalazine-triones under solvent-free conditions. Res Chem Intermed 41, 3675–3681 (2015). https://doi.org/10.1007/s11164-013-1480-x

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