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(E)-2-Benzylidene-7-chloro-9-phenyl-3,4-dihydroacridin-1(2H)-ones: synthesis and larvicidal activity

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Abstract

The purpose of this study was to synthesize (E)-2-benzylidene-7-chloro-9-phenyl-3,4-dihydroacridin-1(2H)-ones and investigate their larvicidal potential against Anopheles stephensi and Hippobosca maculata. Synthetic acridines are used in many commercial applications. The results obtained from FTIR, 1H and 13C NMR, and ESI–MS spectra confirm the synthesis of (E)-2-benzylidene-7-chloro-9-phenyl-3,4-dihydroacridin-1(2H)-ones, 3a–j. Larvae were exposed to different concentrations of compounds, 3a–j for 24 h. All the compounds had moderate activity; maximum efficacy was observed for 3e and 3j.

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Acknowledgments

The study was supported by DST-SERB Fast Track (Sanction No. SR/FT/CS-264/2012), Government of India, New Delhi. The authors gratefully acknowledge DST-FIST for providing NMR facilities to the school. We acknowledge the support extended by VIT-SIF for GC–MS and NMR analysis.

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Authors and Affiliations

  1. Chemistry Research Laboratory, Organic Chemistry Division, School of Advanced Sciences, VIT University, Vellore, 632 014, Tamil Nadu, India

    A. Bharathi & Selvaraj Mohana Roopan

  2. Unit of Nanotechnology and Bioactive Natural Products, Post Graduate and Research Department of Zoology, C. Abdul Hakeem College, Vellore District, Melvisharam, 632509, Tamil Nadu, India

    Abdul Abdul Rahuman & G. Rajakumar

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  1. A. Bharathi
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  2. Selvaraj Mohana Roopan
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Correspondence to Selvaraj Mohana Roopan.

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Bharathi, A., Mohana Roopan, S., Rahuman, A.A. et al. (E)-2-Benzylidene-7-chloro-9-phenyl-3,4-dihydroacridin-1(2H)-ones: synthesis and larvicidal activity. Res Chem Intermed 41, 2453–2464 (2015). https://doi.org/10.1007/s11164-013-1359-x

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