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Synthesis, structure determination, and antioxidant activity of novel 1-pyrazolyl-3-substituted isoquinolines, 1-pyrrolyl 3-substituted isoquinolin-1-amine, and 1-pyrazolonyl-substituted isoquinolines

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Abstract

N-substituted pyrazoles, pyrroles, and pyrazolones have been synthesized from 1,3 diketones, 1,4 diketones or α-haloesters, and hydrazinoisoquinolines. Reaction occurred at room temperature and furnished the desired products in excellent yields. The structures of the synthesized products were confirmed spectroscopically, including use of one dimensional 1H and 13C NMR spectroscopy and two-dimensional H,H-COSY and C,H-COSY. The antioxidant activity of the pyrazoles was evaluated and compared with that of the standard antioxidant BHT.

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Acknowledgments

The authors wish to express their gratitude to Syngene International Limited for their support of the NMR and GC–MS facilities used to carry this research work.

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Authors and Affiliations

  1. Organic and Medicinal Chemistry Research Laboratory, Organic Chemistry Division, School of Advanced Sciences, VIT University, Vellore, 632 014, Tamil Nadu, India

    P. Manivel, K. Prabakaran, Y. Suneel, S. M. Ghouse, P. M. Vivek, E. Ubba, I. Pugazhenthi & Fazlur-Rahman Nawaz Khan

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  1. P. Manivel
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Correspondence to Fazlur-Rahman Nawaz Khan.

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Manivel, P., Prabakaran, K., Suneel, Y. et al. Synthesis, structure determination, and antioxidant activity of novel 1-pyrazolyl-3-substituted isoquinolines, 1-pyrrolyl 3-substituted isoquinolin-1-amine, and 1-pyrazolonyl-substituted isoquinolines. Res Chem Intermed 41, 2081–2094 (2015). https://doi.org/10.1007/s11164-013-1333-7

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