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Antiviral activities of some synthesized methylsulfanyltriazoloquinazoline derivatives

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Abstract

A series of some newly methylsulfanyl-triazoloquinazoline derivatives (1–21) have been tested against Coxsackievirus B4 and Adenovirus type 7. The antiviral activity of the titled compounds against Coxsackie B4 and Adeno type 7 was evaluated in BGM and Hep-2 cell lines. Compounds 4, 5, and 6 represent the most populated set of compounds obtained during this study, and 4 and 6 in particular were found to display the highest activities against Coxsackie B4 and exhibited good effect against Adeno type 7. The % of reduction in the case of Coxsackie B4 titer was 63.3 % (4, 6) and 83.3 % (5), while in Adeno type 7 titer was 63.3, 50, and 66.6 % for 4, 5, and 6, respectively.

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Acknowledgments

The authors extend their appreciation to the Research Centre, College of Pharmacy and the Deanship of Scientific Research at King Saud University for their funding support.

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Authors and Affiliations

  1. Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, P. O. Box 2457, Riyadh, 11451, Saudi Arabia

    Rashad A. Al-Salahi, Mohamed A. Al-Omar, Ibrahim Alswaidan & Mohamed Marzouk

  2. Chemistry of Natural Products Research Group, Center of Excellence for Advanced Sciences, National Research Center, Dokki, Cairo, 12622, Egypt

    Mohamed Marzouk

  3. Food-Borne Viruses Research Group, Center of Excellence for Advanced Sciences, National Research Center, Dokki, Cairo, 12622, Egypt

    Waled M. El-Senousy

  4. Pharmaceutical Chemistry Department, Drug Exploration & Development Chair, College of Pharmacy, King Saud University, Riyadh, 11451, Saudi Arabia

    Mohamed A. Al-Omar & Abd El-Galil E. Amr

  5. Applied Organic Chemistry Department, National Research Center, Dokki, Cairo, 12622, Egypt

    Abd El-Galil E. Amr

Authors
  1. Rashad A. Al-Salahi
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  2. Mohamed A. Al-Omar
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  3. Ibrahim Alswaidan
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  5. Waled M. El-Senousy
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  6. Abd El-Galil E. Amr
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Correspondence to Rashad A. Al-Salahi.

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Al-Salahi, R.A., Al-Omar, M.A., Alswaidan, I. et al. Antiviral activities of some synthesized methylsulfanyltriazoloquinazoline derivatives. Res Chem Intermed 41, 151–161 (2015). https://doi.org/10.1007/s11164-013-1177-1

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  • DOI: https://doi.org/10.1007/s11164-013-1177-1

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