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Synthesis and antimicrobial activities of some newly 2,4,6-tri-substituted pyridine derivatives

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Abstract

A series of novel 2-(2-(substituted benzylidene)hydrazinyl)-N′-(substituted benzylidene)-6-chloropyridine-4-carbohydrazide (5a–e), 2-(2-cycloalkylidenehydrazinyl)-6-chloro-N’-cyclo-alkylidenepyridine-4-carbohydrazide (6a,b), 2-(2-(1-(4-substituted phenyl)ethylidene)hydrazinyl)-6-chloro-N′-(1-(4-substituted phenyl)ethylidene)pyridine-4-carbohydrazide (7a,b) and 2-(2-(1-(pyridinyl)ethylidene)hydrazinyl)-6-chloro-N′-(1-(pyridinyl) ethylidene)pyridine-4-carbo-hydrazide (8a–c) derivatives have been synthesized by treating treating 2-chloro-6-hydrazinoisonicotinic acid hydrazide 4 with selected active reagents. Their structures were confirmed by spectral and analytical data. The synthesized compounds were investigated for antimicrobial activities. The antimicrobial screening showed that many of these obtained compounds have good activities comparable to Streptomycin and Fusidic acid as reference drugs.

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Acknowledgment

The authors extend their appreciation to the Deanship of Scientific Research at King Saud University for funding the work through the research group project No. RGP-VPP-0172.

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Authors and Affiliations

  1. Applied Organic Chemistry Department, National Research Center, Dokki,Cairo, Egypt

    Osama I. Abdel Salam & Abd El-Galil E. Amr

  2. Pharmaceutical Chemistry Department, Drug Exploration & Development Chair, College of Pharmacy, King Saud University, Riyadh, 11451, Saudi Arabia

    Nagy M. Khalifa & Abd El-Galil E. Amr

  3. Department of Chemistry, Faculty of Science, Zagazig University, Zagazig, Egypt

    Said A. Said

Authors
  1. Osama I. Abdel Salam
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  2. Nagy M. Khalifa
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  3. Said A. Said
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  4. Abd El-Galil E. Amr
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Correspondence to Abd El-Galil E. Amr.

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Abdel Salam, O.I., Khalifa, N.M., Said, S.A. et al. Synthesis and antimicrobial activities of some newly 2,4,6-tri-substituted pyridine derivatives. Res Chem Intermed 40, 1147–1155 (2014). https://doi.org/10.1007/s11164-013-1028-0

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  • DOI: https://doi.org/10.1007/s11164-013-1028-0

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