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Tracing of ethyl 2-acetyl-3-(arylamino)butanoate intermediates (β-amino ketones) and their structural confinement

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Abstract

Tracing of ethyl 2-acetyl-3-(phenylamino)butanoate intermediates (β-amino ketones) was performed during the course of N-arylpiperidone synthesis by reaction of aromatic amines, acetaldehyde, and ethyl acetoacetate. The structural confinement and stereochemistry of these molecules were explained by use of 2D NMR spectroscopy and X-ray crystallography.

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Acknowledgment

This work was supported by Department of Science and Technology Government of India (grant no. SR/FTP/CS-108/2006). The authors are thankful to the VIT University management for their generous support and facilities.

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Authors and Affiliations

  1. Synthetic Organic Chemistry Research Laboratory, Organic Chemistry Division, School of Advanced Sciences, VIT University, Vellore, 632 014, Tamil Nadu, India

    K. Rajesh, B. Palakshi Reddy, G. L. Balaji, S. Sarveswari & V. Vijayakumar

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  1. K. Rajesh
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  2. B. Palakshi Reddy
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  3. G. L. Balaji
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  4. S. Sarveswari
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  5. V. Vijayakumar
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Correspondence to V. Vijayakumar.

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Rajesh, K., Palakshi Reddy, B., Balaji, G.L. et al. Tracing of ethyl 2-acetyl-3-(arylamino)butanoate intermediates (β-amino ketones) and their structural confinement. Res Chem Intermed 38, 1629–1635 (2012). https://doi.org/10.1007/s11164-012-0489-x

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  • DOI: https://doi.org/10.1007/s11164-012-0489-x

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