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Cytotoxicity, antioxidant, and antimicrobial activities of novel 2-quinolone derivatives derived from coumarin

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Abstract

Coumarins are important and useful compounds with diverse pharmacological properties. New coumarin derivatives namely N-aminoquinoline-2-one 1, 1-((4-hydroxy-6-methyl-2-oxo-2H-pyran-3-yl)methyleneamino)quinolin-2(1H)-one 2 and 1,1′-(1E,1′E)-(1,4-phenylenebis(methan-1-yl-1-ylidene))bis(azan-1-yl-1-ylidene)diquinolin-2(1H)-one 3, were synthesized and characterized by UV–Vis, FT-IR, and NMR spectra in addition of elemental analysis. The synthesized compounds (2 and 3) show considerable anticancer activity against HEp-2 cell line. Synthesized compounds (2 and 3) were tested against selected types of microbial organisms and showed significant activities. The free-radical scavenging activity of synthesized compounds (2 and 3) have been determined by their interaction with the stable free-radical 1,1-diphenyl-2-picrilhydrazyl (DPPH) and all the compounds have shown encouraging antioxidant activities.

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Authors and Affiliations

  1. Biotechnology Division, Applied Science Department, University of Technology, Baghdad, 10066, Iraq

    Ahmed A. Al-Amiery

  2. Department of Chemical and Processing Engineering, Faculty of Engineering and Built Environment, Universiti of Kebangsaan Malaysia, 43600, Bangi, Selangor, Malaysia

    Ahmed A. Al-Amiery

  3. Department of Chemistry, College of Sciences, Al-Mustansiriyah University, Baghdad, Iraq

    Redha I. H. Al-Bayati & Mahdi F. Radi

  4. Department of Pharmacology, College of Pharmacy, Baghdad University, Baghdad, Iraq

    Kawkab Y. Saour

Authors
  1. Ahmed A. Al-Amiery
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  2. Redha I. H. Al-Bayati
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  3. Kawkab Y. Saour
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  4. Mahdi F. Radi
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Correspondence to Ahmed A. Al-Amiery.

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Al-Amiery, A.A., Al-Bayati, R.I.H., Saour, K.Y. et al. Cytotoxicity, antioxidant, and antimicrobial activities of novel 2-quinolone derivatives derived from coumarin. Res Chem Intermed 38, 559–569 (2012). https://doi.org/10.1007/s11164-011-0371-2

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  • DOI: https://doi.org/10.1007/s11164-011-0371-2

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