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Endothelial dysfunction in diabetes mellitus: Molecular mechanisms and clinical implications

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Abstract

Cardiovascular disease is a major complication of diabetes mellitus, and improved strategies for prevention and treatment are needed. Endothelial dysfunction contributes to the pathogenesis and clinical expression of atherosclerosis in diabetes mellitus. This article reviews the evidence linking endothelial dysfunction to human diabetes mellitus and experimental studies that investigated the responsible mechanisms. We then discuss the implications of these studies for current management and for new approaches for the prevention and treatment of cardiovascular disease in patients with diabetes mellitus.

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Acknowledgments

Drs. Tabit, Hamburg, and Vita received support from the NIH-sponsored Boston University Medical Center Leadership Program in Vascular Medicine (K12 HL083781). Dr. Vita’s work is supported by grants from the NIH (HL083801, HL081587, HL083269, and HL75795).

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  1. Evans Department of Medicine and Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA, USA

    Corey E. Tabit, William B. Chung, Naomi M. Hamburg & Joseph A. Vita

  2. Section of Cardiology, Boston Medical Center, 88 East Newton Street, Boston, MA, 02118, USA

    Joseph A. Vita

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Tabit, C.E., Chung, W.B., Hamburg, N.M. et al. Endothelial dysfunction in diabetes mellitus: Molecular mechanisms and clinical implications. Rev Endocr Metab Disord 11, 61–74 (2010). https://doi.org/10.1007/s11154-010-9134-4

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