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HER2 targeted therapy in breast cancer...beyond Herceptin

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Abstract

HER2, is a member of the ErbB family of receptor tyrosine kinases, that plays a key role in the pathogenesis of breast cancer, and when overexpressed, can correlate with a particularly aggressive clinical phenotype. It is estimated in roughly 18 to 20% of breast cancer patients, there is amplification of the HER2 gene resulting in aberrant overexpression of p185HER2 protein. As such, HER2 represents an attractive therapeutic target. In this review, we explore the clinical evolution of trastuzumab, a humanized monoclonal antibody with high specificity and affinity for the HER2 extracellular domain, and additionally examine more recent efforts targeting the intracellular tyrosine kinase domain of HER2 using small molecule tyrosine kinase inhibitors.

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  1. 111-934 Factor Building, UCLA Center for the Health Sciences, UCLA Campus Mail Code 167817, 10833 Le Conte Avenue, Los Angeles, CA, 90095, USA

    Sumanta Kumar Pal & Mark Pegram

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  1. Sumanta Kumar Pal
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  2. Mark Pegram
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Correspondence to Mark Pegram.

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Pal, S.K., Pegram, M. HER2 targeted therapy in breast cancer...beyond Herceptin. Rev Endocr Metab Disord 8, 269–277 (2007). https://doi.org/10.1007/s11154-007-9040-6

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  • DOI: https://doi.org/10.1007/s11154-007-9040-6

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