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Quality of life in postmenopausal women with osteoporosis: a systematic review and meta-analysis

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Abstract

Purpose

Postmenopausal osteoporosis has become a global trend, which seriously affects women’s quality of life. However, the differences remain unclear in health-related quality of life (HRQoL) among postmenopausal women with normal bone mineral density, osteoporosis, and osteoporotic fractures. The aim of this study was to assess health-related quality of life in women with three different bone states.

Methods

Databases of PubMed, Embase, Cochrane, and Web of Science were based on the search terms, and the search time was set from the inception of each database to January 2022. A study was included if the researchers used a validated quality of life questionnaire to investigate the quality of life of postmenopausal women with osteoporosis or osteoporotic fractures. The random-effect model was used for meta-analysis, and the mean difference with a 95% confidence interval (95%CI) was calculated.

Results

Thirteen studies that met the inclusion criteria were systematically reviewed, involving 2897 postmenopausal women, and 12 of them were included in the meta-analysis. Postmenopausal women with osteoporosis had worse overall HRQoL and different HRQoL dimensions compared with postmenopausal women with normal bone density. Compared with postmenopausal women with osteoporosis, postmenopausal women with osteoporotic fractures had worse overall HRQoL and individual dimensions of HRQoL, especially physical component summary (SMD = − 0.61, 95% CI, − 0.98 to − 0.24). Bone mineral density was positively associated with HRQoL, while fragility fracture severity was negatively associated with HRQoL.

Conclusions

Postmenopausal osteoporosis and fragility fractures reduce HRQoL to varying degrees in women. More research should be done to reduce the incidence of the disease.

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Data availability

Data sharing is not applicable to this article as no datasets were generated or analyzed during the current study.

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Acknowledgements

The authors are grateful to Hailing Guo for her help with the preparation of materials and data collection in this paper.

Funding

The authors have not disclosed any funding.

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Authors and Affiliations

  1. Shi’s Center of Orthopedics and Traumatology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China

    Sasa Gao & Yongfang Zhao

  2. Institute of Traumatology & Orthopedics, Shanghai Academy of Traditional Chinese Medicine, Shanghai, China

    Sasa Gao & Yongfang Zhao

  3. Science and Technology Department of Shanghai University of traditional Chinese medicine, No. 1200 Cailun Road, Pudong New Area, Shanghai, 201203, China

    Yongfang Zhao

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  1. Sasa Gao
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Contributions

All authors contributed to the study conception and design. SG and YZ contributed to materials preparation, data collection, and analysis. SG wrote the first draft of the manuscript  and all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.

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Correspondence to Yongfang Zhao.

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Gao, S., Zhao, Y. Quality of life in postmenopausal women with osteoporosis: a systematic review and meta-analysis. Qual Life Res 32, 1551–1565 (2023). https://doi.org/10.1007/s11136-022-03281-1

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