Abstract
Purpose
To identify the impact of clinical and socio-economic determinants on quality of life (QoL) among breast cancer (BC) survivors 5 years after diagnosis.
Methods
A cross-sectional survey was conducted in women diagnosed in 2007 for primary invasive non-metastatic BC and identified through the Côte d’Or BC registry. QoL was assessed with the Medical Outcomes Study 12-item Short Form Health Survey (SF-12), the European Organization for Research and Treatment of Cancer Quality of Life (EORTC-QLQ-C30) and the breast cancer (EORTC-QLQ-BR23) questionnaires. Social support was assessed with Sarason’s social support questionnaire, and deprivation was assessed by the EPICES questionnaire. Clinical variables were collected through the registry database. Determinants of QoL were identified using multivariable mixed model analysis for each SF-12 dimension. A sensitivity analysis was conducted with multiple imputations on missing data.
Results
Overall, 188 patients on 319 patients (59 %) invited to participate to the survey completed the questionnaires. Five years after breast cancer diagnosis, the disease stages at diagnosis, as well as the treatment received, were not determinants of QoL. Only the age at diagnosis and comorbidities were found to be determinants of QoL.
Conclusions
Five years after BC diagnosis, disease severity and the treatment received did not affect QoL.
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References
Belot, A., Grosclaude, P., Bossard, N., et al. (2008). Cancer incidence and mortality in France over the period 1980–2005. Revue d’Epidemiologie et de Sante Publique, 56, 159–175.
Grosclaude, P., Bossard, N., Remontet, L., et al. (2007). Survie des patients atteints de cancer en France : étude des registres du réseau FRANCIM. Paris: Springer.
Fallowfield, L. (2002). Quality of life: A new perspective for cancer patients. Nature Reviews Cancer, 2, 873–879.
The WHOQOL Groups. (1995). The World Health Organization Quality of Life assessment (WHOQOL): Position paper from the World Health Organization. Social Science and Medicine, 41, 1403.
Montazeri, A. (2008). Health-related quality of life in breast cancer patients: A bibliographic review of the literature from 1974 to 2007. Journal of Experimental & Clinical Cancer Research, 27, 32. doi:10.1186/1756-9966-27-32.
Howard-Anderson, J., Ganz, P. A., Bower, J. E., & Stanton, Al. (2012). Quality of life, fertility concerns, and behavioural health outcomes in younger breast cancer survivors: A systematic review. Journal of the National Cancer Institute, 104, 386–405.
Glaser, A. W., Fraser, L. K., Corner, J., et al. (2013). Patient-reported outcomes of cancer survivors in England 1–5 years after diagnosis: A cross-sectional survey. BMJ Open,. doi:10.1136/bmjopen-2012-002317.
Arndt, V., Stegmaier, C., Ziegler, H., & Brennet, H. (2008). Quality of life over 5 years in women with breast cancer after breast-conserving therapy versus mastectomy: A population-based study. Journal of Cancer Research and Clinical Oncology, 134, 1311–1318.
Reimer, T., & Gerber, B. (2010). Quality-of-life considerations in the treatment of early-stage breast cancer in the elderly. Drugs and Aging, 27, 791–800.
Mols, F., Vingerhoets, A. J., Coebergh, J. W., & van de Poll-Franse, L. V. (2005). Quality of life among long-term breast cancer survivors: A systematic review. European Journal of Cancer, 4, 2613–2619.
Kroenke, C. H., Kwan, M. L., Al, Neugut, et al. (2013). Social networks, social support mechanisms, and quality of life after breast cancer diagnosis. Breast Cancer Research and Treatment, 139, 515–527.
Lu, W., Cui, Y., Chen, X., et al. (2009). Changes in quality of life among breast cancer patients three years post-diagnosis. Breast Cancer Research and Treatment, 114, 357–369.
Klein, D., Mercier, M., Abeillard, E., et al. (2011). Long-term quality of life after breast cancer: A French registry-based controlled study. Breast Cancer Research and Treatment, 129, 125–134.
Aaronson, N. K., Ahmedzai, S., Bergman, B., et al. (1993). The European Organization for Research and Treatment of Cancer QLQ-C30: A quality-of-life instrument for use in international clinical trials in oncology. Journal of the National Cancer Institute, 85, 365–376.
Fayers, P. M., Aaronson, N. K., Bjordal, K., et al. (2001). The EORTC QLQ-C30 scoring manual (3rd ed.). Brussels: EORTC.
Ware, J, Jr, Kosinski, M., & Keller, S. D. (1996). A 12-Item Short-Form Health Survey: Construction of scales and preliminary tests of reliability and validity. Medical Care, 34, 220–233.
Gandek, B., Ware, Je., Aaroson, Nk., et al. (1998). Cross validation of item selection and scoring for the sf-12 health survey in nine countries: Results from the iqola project. International quality of life assessment. Journal of Clinical Epidemiology, 51, 1171–1178.
Ware, J. E., Kosinski, M., Turner-Bowker, D. M., & Gandek, B. (2005). How to score version 2 of the SF-12 health survey (with a supplement documenting version 1). Lincoln, RI: Quality Metric.
Bruchon-Schweitzer, M., Rascle, N., & Sarason, I. G. (2005). The Sarason Social Support Questionnaire (SSQ6). A French adaptation. Psychological Reports, 2005(97), 195–202.
Sass, C., Moulin, J.-J., Guéguen, R., et al. (2006). Le score Epices: Un score individuel de précarité. Construction du score et mesure des relations avec des données de santé, dans une population de 197389 personnes. Bulletin Epidemiologique Hebdomadaire, 14, 93–96.
Singletary, S. E., Allred, C., Ashley, P., et al. (2002). Revision of the American Joint Committee on Cancer Staging System for Breast Cancer. Journal of Clinical Oncology, 20, 3628–3636.
Curran, D., Bacchi, M., Schmitz, S. F., Molenberghs, G., & Sykvester, R. J. (1998). Identifying the types of missingness in quality of life data from clinical trials. Statistics in Medicine, 17, 739–756.
Cottrell, G., Cot, M., & Mary, J. Y. (2009). Multiple imputation of missing at random data: General points and presentation of a Monte-Carlo method. Revue d’Epidemiologie et de Sante Publique, 57, 361–372.
Lee, K. J., & Carlin, J. B. (2010). Multiple imputation for missing data: Fully conditional specification versus multivariate normal imputation. American Journal of Epidemiology, 171, 624–632.
Ganz, P. A., Desmond, K. A., Leedham, B., et al. (2002). Quality of life in long-term, disease-free survivors of breast cancer: A follow-up study. Journal of the National Cancer Institute, 94, 39–49.
Bowen, D. J., Alfano, C. M., McGregor, B. A., et al. (2007). Possible socioeconomic and ethnic disparities in quality of life in a cohort of breast cancer survivors. Breast Cancer Research and Treatment, 106, 85–95.
Zebrack, B. J., Yi, J., Petersen, L., & Ganz, P. A. (2008). The impact of cancer and quality of life for long-term survivors. Psychooncology, 17, 891–900.
Fortim, M., Bravo, G., Hudon, C., et al. (2006). Relationship between multimorbidity and health-related quality of life of patients in primary care. Quality of Life Research, 15, 83–91.
Garcia, E. L., Banegas, J. R., Pérez-Regadera, A. G., Cabrera, R. H., & Rodríguez-Artalejo, F. (2005). Social network and health-related quality of life in older adults: A population-based study in Spain. Quality of Life Research, 14, 511–520.
Acknowledgments
We thank Ludovic Bouzigues for data collection and Philip Bastable, for correcting the manuscript.
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Côte d’Or breast and gynaecological cancer registry has agreement of “Commission Nationale de l’Informatique et des Libertés (CNIL)” DR-2012-038 for collecting data, recording data and carrying out studies with these data.
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Chu, Wo., Dialla, P.O., Roignot, P. et al. Determinants of quality of life among long-term breast cancer survivors. Qual Life Res 25, 1981–1990 (2016). https://doi.org/10.1007/s11136-016-1248-z
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DOI: https://doi.org/10.1007/s11136-016-1248-z