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Predictors of health-related quality of life perceived by end-stage renal disease patients under online hemodiafiltration

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Abstract

Purpose

Patients’ perception of health-related quality of life (HRQOL) is a consistent and powerful predictor of the outcome of end-stage renal disease (ESRD) patients under dialysis. This study aims to identify factors that could affect the HRQOL of ESRD patients under online hemodiafiltration (OL-HDF).

Methods

We evaluated 322 ESRD patients under OL-HDF (59.63 % males; 64.9 ± 14.3 years old) from five dialysis units in the north of Portugal. Socio-demographic data, comorbidities, hematological data, iron status, dialysis adequacy, nutritional and inflammatory markers were collected from patients records. Patient’s reported HRQOL score was assessed by using the Kidney Disease Quality of Life-Short Form (KDQOL-SF).

Results

ESRD patients showed a mean (±SD) of 53.17 % (±15.31 %) in SF-36 total score, 50.17 % (±9.51 %) in the SF-36 mental component summary (MCS) and 49.75 % (±9.44 %) in the SF-36 physical component summary (PCS). Red cell distribution width (RDW), feminine gender and diabetes were found as significant predictors of SF-36 total score of HRQOL, which accounts for 12 % of the total explained variance. Patient satisfaction, RDW, body mass index and gender were identified as predictors for the PCS, which accounts for 22 % of total explained variance. Furthermore, patient satisfaction and dry weight were found as predictors for MCS. These predictors accounted for 28 % of the total explained variance.

Conclusions

Our results showed that the coexistence of diabetes, gender and erythropoietic disturbances are predictors of HRQOL in patients under OL-HDF and suggest that more attention should be given to woman patients, to the improvement of anemia and to diabetic patients, who are more prone to perceive a worst HRQOL.

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Authors and Affiliations

  1. Instituto de Ciências da Saúde, Universidade Católica Portuguesa, Porto, Portugal

    Alexandra Moura

  2. Clínica de Hemodiálise NefroServe, Barcelos, Portugal

    José Madureira & Pablo Alija

  3. Clínica de Hemodiálise NefroServe, Viana do Castelo, Portugal

    João Carlos Fernandes

  4. Centro Hospitalar do Porto, Porto, Portugal

    José Gerardo Oliveira

  5. Clínica de Hemodiálise de Felgueira, Felgueiras, Portugal

    Martin Lopez

  6. Clínica de Hemodiálise de Gondomar, Gondomar, Portugal

    Madalena Filgueiras

  7. Clínica de Hemodiálise NephroCare, Maia, Portugal

    Leonilde Amado, Maria Sameiro-Faria & Vasco Miranda

  8. Núcleo de Estudantes de Estatística, Universidade do Minho, Braga, Portugal

    Edgar Mesquita

  9. Laboratório de Bioquímica, Departamento de Ciências Biológicas, Faculdade de Farmácia, Universidade do Porto, Rua de Jorge Viterbo Ferreira, 228, 4050-313, Porto, Portugal

    Alice Santos-Silva & Elísio Costa

  10. Instituto de Biologia Molecular e Celular, Universidade do Porto, Porto, Portugal

    Alice Santos-Silva & Elísio Costa

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  1. Alexandra Moura
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  2. José Madureira
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  3. Pablo Alija
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  6. Martin Lopez
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  9. Maria Sameiro-Faria
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  13. Elísio Costa
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Correspondence to Elísio Costa.

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Moura, A., Madureira, J., Alija, P. et al. Predictors of health-related quality of life perceived by end-stage renal disease patients under online hemodiafiltration. Qual Life Res 24, 1327–1335 (2015). https://doi.org/10.1007/s11136-014-0854-x

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  • DOI: https://doi.org/10.1007/s11136-014-0854-x

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