Skip to main content

Advertisement

SpringerLink
Log in

Depression and anxiety symptoms in bronchiectasis: associations with health-related quality of life

  • Published:
Quality of Life Research Aims and scope Submit manuscript

Abstract

Background and purpose

Bronchiectasis causes pulmonary infections and loss of lung function, resulting in chronic respiratory symptoms and worsening health-related quality of life. The aims of this study were to measure symptoms of depression and anxiety in a sample of patients with bronchiectasis and evaluate their relationship to health outcomes and health-related quality of life.

Methods

This cross-sectional study included adolescents and adults with bronchiectasis. Patients completed the hospital anxiety and depression scale and the St. George respiratory questionnaire. Health outcome data, including clinical, radiological and spirometric values, were recorded from medical charts.

Results

Ninety-three participants with bronchiectasis of any aetiology were recruited: 20 % had elevated depression-related scores and 38 % had elevated anxiety-related scores. Increased symptoms of depression and anxiety were significantly associated with age; anxiety was associated with more frequent exacerbations. Regression analyses indicated that after controlling for demographic (gender and age) and clinical variables (exacerbations frequency, daily sputum, aetiology and spirometry), both depression and anxiety symptoms predicted significantly worse health-related quality of life. In comparison with other predictors, psychological symptoms explained the largest amount of variance in health-related quality of life.

Conclusions

Symptoms of depression and anxiety were significant predictors of health-related quality of life in patients with bronchiectasis, independently of respiratory involvement, gender, age or other variables.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1

Similar content being viewed by others

References

  1. Floto, R. A. & Haworth, C. S. (Eds.) (2011). Bronchiectasis. European Respiratory Society Monograph. doi:10.1183/1025448x.10005111.

  2. Vendrell, M., de Gracia, J., Olveira, C., Martínez, M. A., Girón, R., Máiz, L., et al. (2008). Diagnosis and treatment of bronchiectasis. Recommendations of the spanish society of pulmonology and thoracic surgery(SEPAR). Archivos de Bronconeumologia, 44, 629–640.

    Article  PubMed  Google Scholar 

  3. Pasteur, M. C., Bilton, D., & Hill, A. T., On behalf of The British Thoracic Society Bronchiectasis (non-CF) Guidelines Group. (2010). British thoracic society for non-CF bronchiectasis. Thorax, 65, i1–i58.

    Article  PubMed  Google Scholar 

  4. O’Leary, C. J., Wilson, C. B., Hansell, D. M., Cole, P. J., Wilson, R., & Jones, P. W. (2002). Relationship between psychological well-being and lung health status in patients with bronchiectasis. Respiratory Medicine, 96, 686–692.

    Article  PubMed  Google Scholar 

  5. Abbott, J., Hart, A., Morton, A., & Gee, L. (2008). Conway S. Health-related quality of life in adults with cystic fibrosis: The role of coping. Journal of Psychosomatic Research.

    Google Scholar 

  6. Olveira, G., Olveira, C., Gaspar, I., Cruz, I., Dorado, A., Pérez-Ruiz, E., et al. (2010). Validation of the Spanish version of the revised cystic fibrosis quality of life questionnaire in adolescents and adults (CFQR 14 + Spain). Archivos de Bronconeumologia, 46, 165–175.

    Article  PubMed  Google Scholar 

  7. US Food and Drug Administration (2009). Guidance for industry patient-reported outcome.http://www.fda.gov/downloads/Drugs/GuidanceComplianceRegulatoryInformation/Guidances/UCM193282.pdf.

  8. Martínez-García, M. A., Perpiñá Tordera, M., Román Sánchez, P., & Soler Cataluña, J. J. (2005). Internal consistency and validity of the Spanish version of the St. George’s respiratory questionnaire for use in patients with clinically stable bronchiectasis. Archivos de Bronconeumologia, 41, 110–117.

    Article  PubMed  Google Scholar 

  9. Padilla, A., Olveira, G., Olveira, C., Dorado, A., Plata, A. J., Gaspar, I., et al. (2007). Validity and reliability of the St George’s respiratory questionnaire in adults with cystic fibrosis. Archivos de Bronconeumologia, 43, 205–211.

    Article  PubMed  Google Scholar 

  10. Martínez-García, M. A., Perpiñá-Tordera, M., Román-Sánchez, P., & Soler-Cataluña, J. J. (2005). Quality-of-life determinants in patients with clinically stable bronchiectasis. Chest, 128(739–45), 12.

    Google Scholar 

  11. Quittner, A. L., Schechter, M., Rasouliyan, R., Haselkom, T., Pasta, D. J., & Wagener, J. S. (2010). Impact of socioeconomic status, race, and ethnicity on quality of life in patients with cystic fibrosis. Chest, 137, 642–650.

    Article  PubMed  Google Scholar 

  12. Cruz, I., Marciel, K. K., Quittner, A. L., & Schechter, M. S. (2009). Anxiety and depression in cystic fibrosis. Seminars in Respiratory and Critical Care Medicine, 30, 569–578.

    Article  PubMed  Google Scholar 

  13. Katon, W., Lin, E. H., & Kroenke, K. (2007). The association of depression and anxiety with medical symptom burden in patients with chronic medical illness. General Hospital Psychiatry, 29, 147–155.

    Article  PubMed  Google Scholar 

  14. Roy-Byrne, P. P., Davidson, K. W., Kessler, R. C., Asmundson, G. J., & Goodwin, R. D. (2008). Anxiety disorders and comorbid medical illness. General Hospital Psychiatry, 30, 208–225.

    Article  PubMed  Google Scholar 

  15. U.S. Preventive Task Force (2009). Screening for depression in adults: U.S. Preventive services task force recommendation stastement. Annals of Internal Medicine 151:784–792.

    Google Scholar 

  16. Alonso, J., Angermeyer, M. C., Bernert, S., Bruffaerts, R., Brugha, T. S., Bryson, H., et al. (2004). Disability and quality of life impact of mental disorders in Europe: results from the European study of the epidemiology of mental disorders (ESEMeD) project. Acta Psychiatrica Scand., 109, 38–46.

    Article  Google Scholar 

  17. Haro, J. M., Palacín, C., Vilagut, G., Martínez, M., Bernal, M., Luque, I., et al. (2006). Prevalencia de los trastornos mentales y factores asociados: resultados del estudio ESEMeD-España. Medical Clinics (Barc), 126, 445–451.

    Article  Google Scholar 

  18. Riekert, K. A., Bartlett, S. J., Boyle, M. P., Krishnan, J. A., & Rand, C. S. (2007). The association between depression,lung function, and health-related quality of life among adults with cystic fibrosis. Chest, 132, 231–237.

    Article  PubMed  Google Scholar 

  19. Naidich, D. P., McCauley, D. I., Khouri, N. F., Stitik, F. P., & Siegelman, S. S. (1982). Computed tomography of bronchiectasis. Journal of Computer Assisted Tomography, 6, 437–444.

    Article  PubMed  CAS  Google Scholar 

  20. Roca, J., Sanchis, J., Agustí Vidal, A., Segarra, F., Navajas, D., Rodriguez-Roisin, R., et al. (1986). Spirometric reference values for a Mediterranean population. Bulletin Européen de Physiopathologie Respiratoire, 22, 217–224.

    PubMed  CAS  Google Scholar 

  21. Bhalla, M., Turcios, N., Aponte, V., Jenkins, M., Leitman, B. S., McCauley, D. I., et al. (1991). Cystic fibrosis: Scoring system with thin-section CT. Radiology, 179, 783–788.

    PubMed  CAS  Google Scholar 

  22. ATS statement. (2002). Guidelines for the six-minute walk test. American Journal of Respiratory and Critical Care Medicine 66:111–117.

    Google Scholar 

  23. Zigmond, A. S., & Snaith, R. P. (1983). The hospital anxiety and depression scale. Acta Psychiatrica Scand., 67, 361–370.

    Article  CAS  Google Scholar 

  24. Herrero, M. J., Blanch, J., Peri, J. M., De Pablo, J., Pintor, L., & Bulbena, A. (2003). A validation study of the hospital anxiety and depression scale (HADS) in a Spanish population. General Hospital Psychiatry, 25, 277–283.

    Article  PubMed  CAS  Google Scholar 

  25. Kunik, M. E., Roundy, K., Veazey, C., Souchek, J., Richardson, P., Wray, N. P., et al. (2005). Surprisingly high prevalence of anxiety and depression in chronic breathing disorders. Chest, 127, 1205–1211.

    Article  PubMed  Google Scholar 

  26. Goldbeck, L., Besier, T., Hinz, A., Singer, S., Quittner, A. L., & TIDES study group. (2010). Prevalence of anxious and depressive symptoms in German patients with Cystic Fibrosis. Chest, 138, 929–936.

    Article  PubMed  Google Scholar 

  27. Sawicki, G. S., Sellers, D. E., & Robinson, W. M. (2011). Associations between illness perceptions and health-related quality of life in adults with cystic fibrosis. Journal of Psychosomatic Research, 70(2), 161–167.

    Article  PubMed  Google Scholar 

  28. Burker, E. J., Sedway, J., & Carone, S. (2004). Psychological and educational factors: Better predictors of work status tan FEV1 in adults with cystic fibrosis. Pediatric Pulmonology, 38, 413–418.

    Article  PubMed  Google Scholar 

  29. Maurer, J., Rebbapragada, V., Borson, S., Goldstein, R., Kunik, M. E., Yohannes, A. M., et al. (2008). ACCP workshop panel on anxiety and depression in COPD. Anxiety and depression in COPD: current understanding, unanswered questions, and research needs. Chest, 134, 43S–56S.

    Article  PubMed  Google Scholar 

  30. Quittner AL, Cruz I, Blackwell LS, Schechter MS. (2010). The international depression and anxiety epidemiological study (TIDES): Preliminary results from the United States. Pediatric Pulmonology, 45(Suppl. 33), 445S.

    Google Scholar 

  31. Quittner, A. L., Cruz, I., & Marciel, K. K. (2009). A new PRO for non-CF bronchiectasis: Associations between the QOL-B and health outcomes. [Abstract]. European Respiratory Journal, 34(Suppl. 53), 1010S.

    Google Scholar 

Download references

Acknowledgments

This study was supported in part by a grant from Neumosur 05/2008 (Andalusian Society of Pneumology and Thoracic Surgery) and CIBERDEM (CIBER of Diabetes and Associated Metabolic Diseases).

Conflict of interest

Casilda Olveira has no conflicts of interest to disclose. Gabriel Olveira has no conflicts of interest to disclose. Inmaculada Gaspar has no conflicts of interest to disclose. Antonio Dorado has no conflicts of interest to disclose. Francisco Espildora has no conflicts of interest to disclose. Ivette Cruz has no conflicts of interest to disclose. Federico Soriguer has no conflicts of interest to disclose. Dr. Quittner serves in the North American Scientific Advisory Group of Genentech, is a consultant for Novartis and Gilead Sciences and receives investigator-initiated grants from Gilead Sciences and from Novartis.

Author information

Authors and Affiliations

  1. Pneumology Service, Carlos Haya University Hospital, Avenida Carlos Haya, 29010, Malaga, Spain

    Casilda Olveira, Antonio Dorado & Francisco Espildora

  2. Endocrinology and Nutrition Service, Nutrition Unit, Carlos Haya University Hospital, 4ª planta, Pabellón A, Avenida Carlos Haya, 29010, Malaga, Spain

    Gabriel Olveira & Federico Soriguer

  3. CIBERDEM, CIBER of Diabetes and Associated Metabolic Diseases (Instituto de Salud Carlos III), Madrid, Spain

    Gabriel Olveira & Federico Soriguer

  4. Pneumology Service, Hospital Costa del Sol, A.S. Costa del Sol.Autovía A-7 km 187, 29603, Marbella, Málaga, Spain

    Inmaculada Gaspar

  5. Department of Psychology, University of Miami, 5665 Ponce de Leon Blvd, Coral Gables, FL, 33146-2070, USA

    Ivette Cruz & Alexandra L. Quittner

  6. Department of Pediatrics, University of Miami, 5665 Ponce de Leon Blvd, Coral Gables, FL, 33146-2070, USA

    Ivette Cruz

Authors
  1. Casilda Olveira
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Gabriel Olveira
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Inmaculada Gaspar
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Antonio Dorado
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Ivette Cruz
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Federico Soriguer
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Alexandra L. Quittner
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Francisco Espildora
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Gabriel Olveira.

Additional information

The work was performed at Pneumology and Endocrinology-Nutrition Services, Carlos Haya University Hospital, Malaga, Spain.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Olveira, C., Olveira, G., Gaspar, I. et al. Depression and anxiety symptoms in bronchiectasis: associations with health-related quality of life. Qual Life Res 22, 597–605 (2013). https://doi.org/10.1007/s11136-012-0188-5

Download citation

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11136-012-0188-5

Keywords

Search

Navigation