Abstract
Objective
To correlate quality of life (QoL) and physical limitations in histological proven primary brain tumor patients using a battery of generic, disease-specific and symptom questionnaires.
Methods
Thirty patients with primary brain tumors were selected from a neuro-oncology outpatient clinic. The FACT-Br Functional Assessment of Cancer Therapy-Brain (specific quality of life questionnaire for patients with brain tumors), SF-36 (generic quality of life questionnaire), HADS (anxiety and depression), and Barthel Index (functionality scale) were answered by the patients at the same interview.
Results
The Barthel index did not demonstrate correlation with any subscale of the FACT-Br questionnaire. The HADS had a negative correlation with all FACT-Br subscales and its total score. The SF-36 had a significant weak to moderate correlation with the FACT-Br questionnaire.
Conclusion
Considering that the FACT-Br is a quick specific questionnaire, it can be a valuable and simple option in evaluating QoL in brain tumor patients with good functional capacity.
Similar content being viewed by others
References
Salander, P. (1996). Brain tumor as a threat to life and personality: The spouse’s perspective. Journal of Psychosocial Oncology, 14, 1–18.
Osoba, D., Brada, M., Prados, M. D., & Yung, W. K. (2000). Effect of disease burden on health-related quality of life in patients with malignant gliomas. Neuro Oncology, 2, 221–228.
Heimans, J. J., & Taphoorn, M. J. B. (2002). Impact of brain tumour treatment on quality of life. Journal of Neurology, 249, 955–960.
Gustafsson, M., Edvardsson, T., & Ahlstrom, G. (2006). The relationship between function, quality of life and coping in patients with low-grade gliomas. Supportive Care in Cancer, 14, 1205–1212.
Liu, R., Page, M., Solheim, K., Fox, S., & Chang, S. M. (2009). Quality of life in adults with brain tumors: Current knowledge and future directions. Neuro-Oncology, 11, 330–339.
Addeo, R., Caraglia, M., Faiola, V., Capasso, E., Vincenzi, B., Montella, L., et al. (2007). Concomitant treatment of brain metastasis with whole brain radiotherapy [WBRT] and temozolomide [TMZ] is active and improves quality of life. BMC Cancer, 7, 18.
Bezjak, A., Adam, J., Barton, R., Panzarella, T., Laperriere, N., Wong, C. S., et al. (2002). Symptom response after palliative radiotherapy for patients with brain metastases. European Journal of Cancer, 38(4), 487–496.
Sehlen, S., Lenk, M., Hollenhorst, H., Schymura, B., Aydemir, U., Herschbach, P., et al. (2003). Quality of life (QoL) as predictive mediator variable for survival in patients with intracerebral neoplasma during radiotherapy. Onkologie, 26(1), 38–43.
Carr, A. J., Gibson, B., & Robinson, P. G. (2001). Is quality of life determined by expectations or experience? BMJ, 322, 1240–1243.
Litofsky, N. S., Farace, E., Anderson, F., Jr., Meyers, C. A., Huang, W., Laws, E. R., Jr., et al. (2004). Depression in patients with high-grade glioma: Results of the Glioma Outcomes Project. Neurosurgery, 54(2), 358–366.
Pelletier, G., Verhoef, M. J., Khatri, N., & Hagen, N. (2002). Quality of life in brain tumor patients: The relative contributions of depression, fatigue, emotional distress, and existential issues. Journal of Neuro-oncology, 57, 41–49.
Mainio, A., Hakko, H., Niemela, A., Koivukangas, J., & Rasanen, P. (2006). Gender difference in relation to depression and quality of life among patients with a primary brain tumor. European Psychiatry, 21, 194–199.
Mainio, A., Tuunanen, S., Hakko, H., Niemela, A., Koivukangas, J., & Rasanen, P. (2006). Decreased quality of life and depression as predictors for shorter survival among patients with low-grade gliomas: A follow-up from 1990 to 2003. European Archives of Psychiatry and Clinical Neuroscience, 256, 516–521.
Brown, P. D., Maurer, M. J., Rummans, T. A., Pollock, B. E., Ballman, K. V., Sloan, J. A., et al. (2005). A prospective study of quality of life in adults with newly diagnosed high-grade gliomas: The impact of the extent of resection on quality of life and survival. Neurosurgery, 57, 495–504.
Ribeiro, V. M. (1997). Alfabetismo funcional: Referências conceituais e metodológicas para a pesquisa. Educação e Sociedade, 18(60), 144–158.
Bertolucci, P. H. F., Brucki, S. M. D., & Campacci, S. R. (1994). The mini-mental state examination in a general population: Impact of educational status. Arquivos de neuro-Psiquiatria, 52(1), 1–7.
http://www.facit.org/qview/translations.aspx? Accessed June 20, 2010.
Ciconelli, R. M., Ferraz, M. B., Santos, W., Meinäo, I., & Quaresma, M. R. (1999). Tradução para a língua portuguesa e validação do questionário genérico de avaliação de qualidade de vida SF-36 (Brasil SF-36). Revista Brasileira de Reumatologia, 39(3), 143–150. http://www.sbr.org.br/publicacoes/revista/1999%2039%2003%20p%20143-150%20Mai%20Jun.pdf.
Ballenger, C. J., Davidson, J. R., Lecrubier, Y., Nutt, D. J., Jones, R. D., Berard, R. M., et al. (2001). Consensus statement on depression, anxiety, and oncology. Journal of Clinical Psychiatry, 62(Suppl 8), 64–67.
Zigmond, A. S., & Snaith, R. P. (1983). The hospital anxiety and depression scale. Acta Psychiatrica Scandinavica, 67(6), 361–370.
Botega, N. J., Ponde, M. P., Medeiros, P., Lima, M. G., & Guerreiro, C. A. M. (1998). Validação da escala hospitalar de ansiedade e depressão (HAD) em pacientes epiléticos ambulatoriais. Jornal Brasileiro de Psiquiatria, 47(6), 258–289.
Botega, N. J., Bio, M. R., Zomignani, M. A., Garcia, C., Jr., & Pereira, W. A. B. (1995). Transtornos do humor em enfermaria de clínica médica e validação de escala de medida (HAD) de ansiedade e depressão. Revista de Saúde Pública, 29(5), 355–363.
Mahoney, F. I., & Barthel, D. W. (1965). Functional evaluation: The Barthel Index. Maryland State Medical Journal, 14, 61–65.
Araújo, F., Ribeiro, J. L. P., Oliveira, A., Pinto, C. (2007). Validação do Índice de Barthel numa amostra de idosos não institucionalizados. Revista Portuguesa de Saúde Pública, 25(2), 59–66. http://www.ensp.unl.pt/dispositivos-de-apoio/cdi/cdi/sector-de-publicacoes/revista/2000-2008/pdfs/05_02_2007.pdf.
Portney, L. G., & Watkinis, M. P. (1993). Foundations of clinical Research. Applications to pratice. USA: Ed Appleton e Lange.
Franceschini, J., Santos, A. A., El Mouallem, I., Jamnik, S., Uehara, C., Fernandes, A. L. G., et al. (2008). Avaliação da qualidade de vida em pacientes com câncer de pulmão através da aplicação do questionário Medical Outcomes Study 36-item Short-Form Health Survey. Jornal Brasileiro de Pneumologia, 34(6), 387–393.
Lovely, M. P., Miaskowski, C., & Dodd, M. (1999). Relationship between fatigue and quality of life in patients with glioblastoma multiformae. Oncology Nursing Forum, 26(5), 921–925.
Weitzner, M. A., Meyers, C. A., Gelke, C. K., Byrne, K. S., Cella, D. F., & Levin, V. A. (1995). The Functional Assessment of Cancer Therapy (FACT) scale. Development of a brain subscale and revalidation of the general version (FACT-G) in patients with primary brain tumors. Cancer, 75(5), 1151–1161.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Gazzotti, M.R., Malheiros, S.M.F., Batan Alith, M. et al. Quality of life and physical limitations in primary brain tumor patients. Qual Life Res 20, 1639–1643 (2011). https://doi.org/10.1007/s11136-011-9908-5
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s11136-011-9908-5