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Impact of depression on quality of life in people living with human T cell lymphotropic virus type 1 (HTLV-1) in Salvador, Brazil

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Abstract

Purpose

A previous study found the prevalence of depression in HTLV-1-infected patients to be approximately 30%, but few studies have attempted to correlate depression with quality of life (QOL) in these patients. The present study investigates the association between depression and QOL in people living with HTLV-1.

Methods

A clinical-epidemiological questionnaire, the Mini International Neuropsychiatric Interview and the WHOQOL-Bref were applied to 88 HTLV-1-infected patients (32 with TSP/HAM) at the HTLV Center of the Bahiana School of Medicine and Public Health, Salvador, Brazil.

Results

The prevalence of depression among people living with HTLV-1 was 34.1%. Depression was significantly associated with a poor QOL in the physical, psychological, social relationship and environment domains, when controlling for other variables, such as gender, age, time of knowledge of serological diagnosis and presence of tropical spastic paraparesis/HTLV-1associated myelopathy (TSP/HAM). Moreover, patients with TSP/HAM experienced a reduction in their QOL in the physical, psychological and environment domains.

Conclusion

Our results showed that depression negatively affects the quality of life of people living with HTLV-1, regardless of the presence of TSP/HAM. Since it is possible to improve a patient’s QOL by treating depression, psychological evaluations are strongly recommended as a measure to integrate the treatment protocols of HTLV-1 intervention programs.

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References

  1. Poiesz, B. J., Ruscetti, F. W., Gazdar, A. F., Bunn, P. A., & Minna, J. D. (1980). Gallo RC: Detection and isolation of type C retrovirus particles from fresh and cultured lymphocytes of a patient with cutaneous T-cell lymphoma. Proceedings of the National Academy of Sciences of the United States of America, 77, 7415–7419.

    Article  PubMed  CAS  Google Scholar 

  2. de Thé, G., Bomford, R. (1993). An HTLV-I vaccine: Why, how, for whom? AIDS Research and Human Retroviruses, 9, 381–386.

    Article  PubMed  Google Scholar 

  3. Hlela, C., Shepperd, S., Khumalo, N. P., & Taylor, G. P. (2009). The prevalence of human T-cell lymphotropic virus type 1 in the general population is unknown. AIDS Reviews, 11, 205–214.

    PubMed  Google Scholar 

  4. Carneiro-Proietti, A. B., Catalan-Soares, B., Proietti, F. A., & Group GIH-IR. (2002). Human T cell lymphotropic viruses (HTLV-I/II) in South America: should it be a public health concern? Journal of Biomedical Science, 9, 587–595.

    Article  PubMed  Google Scholar 

  5. Galvão-Castro, B., Loures, L., Rodriques, L. G., Sereno, A., Ferreira Júnior, O. C., Franco, L. G., et al. (1997). Distribution of human T-lymphotropic virus type I among blood donors: a nationwide Brazilian study. Transfusion, 37, 242–243.

    Article  PubMed  Google Scholar 

  6. Dourado, I., Alcantara, L. C., Barreto, M. L., da Gloria Teixeira, M., & Galvão-Castro, B. (2003). HTLV-I in the general population of Salvador, Brazil: a city with African ethnic and sociodemographic characteristics. Journal of Acquired Immune Deficiency Syndromes, 34, 527–531.

    Article  PubMed  Google Scholar 

  7. Yoshida, M., Miyoshi, I., & Hinuma, Y. (1982). Isolation and characterization of retrovirus from cell lines of human adult T-cell leukemia and its implication in the disease. Proceedings of the National Academy of Sciences of the United States of America, 79, 2031–2035.

    Article  PubMed  CAS  Google Scholar 

  8. Gessain, A., Barin, F., Vernant, J. C., Gout, O., Maurs, L., Calender, A., et al. (1985). Antibodies to human T-lymphotropic virus type-I in patients with tropical spastic paraparesis. Lancet, 2, 407–410.

    Article  PubMed  CAS  Google Scholar 

  9. Osame, M., Izumo, S., Igata, A., Matsumoto, M., Matsumoto, T., Sonoda, S., et al. (1986). Blood transfusion and HTLV-I associated myelopathy. Lancet, 2, 104–105.

    Article  PubMed  CAS  Google Scholar 

  10. Merle, H., Smadja, D., Le Hoang, P., Bera, O., Cabre, P., Landau, M., et al. (1996). Ocular manifestations in patients with HTLV-I associated infection–a clinical study of 93 cases. Japanese Journal of Ophthalmology, 40, 260–270.

    PubMed  CAS  Google Scholar 

  11. Castro-Lima Vargens, C., Grassi, M. F., Boa-Sorte, N., Rathsam-Pinheiro, R. H., Olavarria, V. N., de Almeida Kruschewsky, R., et al. (2011).Keratoconjunctivitis sicca of human T cell lymphotropic virus type 1 (HTLV-1) infected individuals is associated with high levels of HTLV-1 proviral load. J Clin Virol.

  12. Netto, E. C., & Brites, C. (2011). Characteristics of chronic pain and its impact on quality of life of patients with HTLV-1-associated myelopathy/tropical spastic paraparesis (TSP/HAM). Clinical Journal of Pain, 27, 131–135.

    Article  PubMed  Google Scholar 

  13. De Castro-Costa, C. M., Araújo, A. Q., Barreto, M. M., Takayanagui, O. M., Sohler, M. P., da Silva, E. L., et al. (2006). Proposal for diagnostic criteria of tropical spastic paraparesis/HTLV-I-associated myelopathy (TSP/HAM). AIDS Research and Human Retroviruses, 22, 931–935.

    Article  PubMed  Google Scholar 

  14. Galvão-Phileto, A., Pereira, I., Lima, N., Nunes, C., Seabra, A., Fereira, T., et al. (2006). Avaliação dos indicadores de saúde mental e do nível de depressão (ISMND) em indivíduos infectados por HTLV-1. Revista Da Sociedade Brasileira de Medicina Tropical, 39, 42.

    Google Scholar 

  15. Stumpf, B. P., Carneiro-Proietti, A. B., Proietti, F. A., Rocha, F. L., & Group IHR. (2008). Higher rate of major depression among blood donor candidates infected with human t-cell lymphotropic virus type 1. International Journal of Psychiatry in Medicine, 38, 345–355.

    Article  PubMed  Google Scholar 

  16. Carvalho, A. G., Galvão-Phileto, A. V., Lima, N. S., Jesus, R. S., Galvão-Castro, B., & Lima, M. G. (2009). Frequency of mental disturbances in HTLV-1 patients in the state of Bahia, Brazil. Brazilizian Journal of Infect Diseases, 13, 5–8.

    Article  Google Scholar 

  17. Castro, N. M., Rodrigues, W., Freitas, D. M., Muniz, A., Oliveira, P., & Carvalho, E. M. (2007). Urinary symptoms associated with human T-cell lymphotropic virus type I infection: evidence of urinary manifestations in large group of HTLV-I carriers. Urology, 69, 813–818.

    Article  PubMed  Google Scholar 

  18. Diniz, M. S., Feldner, P. C., Castro, R. A., Sartori, M. G., & Girão, M. J. (2009). Impact of HTLV-I in quality of life and urogynecologic parameters of women with urinary incontinence. European Journal of Obstetrics, Gynecology, and Reproductive Biology, 147, 230–233.

    Article  PubMed  Google Scholar 

  19. Shublaq, M., Orsini, M., & Puccioni-Sohler, M. (2011). Implications of TSP/HAM functional incapacity in the quality of life. Arquivos de neuro-psiquiatria, 69, 208–211.

    PubMed  Google Scholar 

  20. Rocha, N. S., & Fleck, M. P. (2010). Evaluation of quality of life in adults with chronic health conditions: the role of depressive symptoms. Revista brasileira de psiquiatria, 32, 119–124.

    Article  PubMed  Google Scholar 

  21. Azevêdo, E. S., Fortuna, C. M., Silva, K. M., Sousa, M. G., Machado, M. A., Lima, A. M., et al. (1982). Spread and diversity of human populations in Bahia, Brazil. Human Biology, 54, 329–341.

    PubMed  Google Scholar 

  22. Amorim, P. (2000). Mini International Neuropsychiatric Interview (MINI): validação de entrevista breve para diagnóstico de transtornos mentais. Revista Brasileira de Psiquiatria, 22, 106–115.

    Article  Google Scholar 

  23. Development of the World Health Organization. (1998). WHOQOL-BREF quality of life assessment. The WHOQOL Group. Psychological Medicine, 28, 551–558.

    Article  Google Scholar 

  24. Fleck, M. P., Louzada, S., Xavier, M., Chachamovich, E., Vieira, G., Santos, L., et al. (2000). Application of the Portuguese version of the abbreviated instrument of quality life WHOQOL-bref. Revista de Saude Publica, 34, 178–183.

    Article  PubMed  CAS  Google Scholar 

  25. Berlim, M. T., Pavanello, D. P., Caldieraro, M. A., & Fleck, M. P. (2005). Reliability and validity of the WHOQOL BREF in a sample of Brazilian outpatients with major depression. Quality of Life Research, 14, 561–564.

    Article  PubMed  Google Scholar 

  26. Almeida-Filho, N., Lessa, I., Magalhães, L., Araúho, M. J., Aquino, E., & de Jesus, M. J. (2007). Co-occurrence patterns of anxiety, depression and alcohol use disorders. European Archives of Psychiatry and Clinical Neuroscience, 257, 423–431.

    Article  PubMed  Google Scholar 

  27. Fullerton, C., Florenzano, R., & Acuña, J. (2000). Comorbidity of chronic diseases and psychiatric disorders among patients attending public primary care. Revista Medica de Chile, 128, 729–734.

    PubMed  CAS  Google Scholar 

  28. Penzak, S. R., Reddy, Y. S., & Grimsley, S. R. (2000). Depression in patients with HIV infection. American Society of Health-System Pharmacists, 57, 376–386, quiz 387–379.

    CAS  Google Scholar 

  29. Valente, S. M. (2003). Depression and HIV disease. Journal of Association of Nurses in AIDS Care, 14, 41–51.

    Article  Google Scholar 

  30. Cruz, L. N., Fleck, M. P., & Polanczyk, C. A. (2010). Depression as a determinant of quality of life in patients with chronic disease: data from Brazil. Social Psychiatry and Psychiatric Epidemiology, 45, 953–961.

    Article  PubMed  Google Scholar 

  31. Noble, J., Greene, H., & Levinson, W. (2001). Textbook of Primary Care Medicine (3rd ed.). Philadelphia: Mosby.

    Google Scholar 

  32. Bonicatto, S. C., Dew, M. A., Zaratiegui, R., Lorenzo, L., & Pecina, P. (2001). Adult outpatients with depression: worse quality of life than in other chronic medical diseases in Argentina. Social Science and Medicine, 52, 911–919.

    Article  PubMed  CAS  Google Scholar 

  33. Goncalves, D. U., Proietti, F. A., Barbosa-Stancioli, E. F., Martins, M. L., Ribas, J. G., Martins-Filho, O. A., et al. (2008). HTLV-1-associated myelopathy/tropical spastic paraparesis (TSP/HAM) inflammatory network. Inflamm Allergy Drug Targets, 7, 98–107.

    Article  PubMed  CAS  Google Scholar 

  34. Raison, C. L., Lowry, C. A., & Rook, G. A. (2010). Inflammation, sanitation, and consternation: loss of contact with coevolved, tolerogenic microorganisms and the pathophysiology and treatment of major depression. Archives of General Psychiatry, 67, 1211–1224.

    Article  PubMed  CAS  Google Scholar 

  35. Dowlati, Y., Herrmann, N., Swardfager, W., Liu, H., Sham, L., Reim, E. K., et al. (2010). A meta-analysis of cytokines in major depression. Biological Psychiatry, 67, 446–457.

    Article  PubMed  CAS  Google Scholar 

  36. Schmidt, H. D., Shelton, R. C., & Duman, R. S. (2011) Functional biomarkers of depression: diagnosis, treatment, and pathophysiology. Neuropsychopharmacology.

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Acknowledgments

We would like to thank Ms. Sonia Rangel, Mr. Noilson L. Gonçalves and Andris K. Walter for the recruitment of patients, technical assistance and English revision, respectively.

Author information

Authors and Affiliations

  1. Escola Bahiana de Medicina e Saúde Pública, Salvador, BA, Brazil

    Ana Verena Galvão-Castro, Ney Boa-Sorte, Ramon Almeida Kruschewsky, Maria Fernanda Rios Grassi & Bernardo Galvão-Castro

  2. Escola Bahiana de Medicina e Saúde, Pública and Fundação Oswaldo Cruz, Salvador, BA, Brazil

    Maria Fernanda Rios Grassi & Bernardo Galvão-Castro

Authors
  1. Ana Verena Galvão-Castro
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  2. Ney Boa-Sorte
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  3. Ramon Almeida Kruschewsky
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  4. Maria Fernanda Rios Grassi
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  5. Bernardo Galvão-Castro
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Corresponding author

Correspondence to Bernardo Galvão-Castro.

Additional information

Ana Verena Galvão-Castro and Ney Boa-Sorte contributed equally to this work.

This article is part of the Masters (MSc) thesis of Ana Verena Galvão-Castro of the Bahiana School of Medicine and Public Health, Postgraduate Course in Medicine and Human Health.

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Galvão-Castro, A.V., Boa-Sorte, N., Kruschewsky, R.A. et al. Impact of depression on quality of life in people living with human T cell lymphotropic virus type 1 (HTLV-1) in Salvador, Brazil. Qual Life Res 21, 1545–1550 (2012). https://doi.org/10.1007/s11136-011-0066-6

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  • DOI: https://doi.org/10.1007/s11136-011-0066-6

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