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Health-related quality of life in Chinese patients with chronic prostatitis/chronic pelvic pain syndrome

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Abstract

Objective

To examine the health-related quality of life (HRQoL) and factors associated with HRQoL in Chinese patients with chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) using two generic preference-based HRQoL instruments, EQ-5D (plus EQ-VAS) and SF-6D, with the results compared with general population.

Method

CP/CPPS patients were recruited from two tertiary referral hospitals, and the general populations were randomly approached. After informed consent, subjects were interviewed using EQ-5D, EQ-VAS and SF-6D, and their socio-demographic and medical information was solicited.

Results

Compared to the general population (n = 364), CP/CPPS patients (n = 268) reported significantly worse HRQoL with median score of the EQ-5D utility index (0.73 vs. 0.85), SF-6D utility index (0.76 vs. 0.81), and EQ-VAS (70.0 vs. 85.0). Multiple linear regression analyses showed pain symptom had the strongest predictive power for HRQoL, compared to symptom duration and urinary symptom. Socio-demographic factors and comorbidities did not significantly contribute to poorer HRQoL.

Conclusion

CP/CPPS patients experienced deteriorated HRQoL with lower health-related utility scores compared to general population, and pain severity was the main physical symptom predicting decreased health-related utility. Further studies are needed to provide the reference utility index for the comparison and better characterizing the influence of geographic and cultural factors on variation of health-related utility of CP/CPPS patients.

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Abbreviations

CP/CPPS:

Chronic prostatitis/chronic pelvic pain syndrome

CUA:

Cost-utility analysis

HRQoL:

Health-related quality of life

MID:

Minimally important difference

MLR:

Multiple linear regressions

NIH-CPSI:

National Institutes of Health Chronic Prostatitis Symptom Index

IQR:

Interquartile range

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Authors and Affiliations

  1. Discipline of Pharmacy & Experimental Pharmacology, School of Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan, NSW, 2308, Australia

    Fei-Li Zhao & Shu-Chuen Li

  2. Department of Pharmacy, 306 Hospital of PLA, Beijing, China

    Ming Yue

  3. Department of Urology, The First People’s Hospital of Yunnan Province, Yunnan, China

    Hua Yang & Tian Wang

  4. Department of Urology, 306 Hospital of PLA, Beijing, China

    Jiu-Hong Wu

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  1. Fei-Li Zhao
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  2. Ming Yue
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  3. Hua Yang
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  4. Tian Wang
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  6. Shu-Chuen Li
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Correspondence to Shu-Chuen Li.

Additional information

Jiu-Hong Wu and Shu-Chuen Li contributed equally to this manuscript.

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Zhao, FL., Yue, M., Yang, H. et al. Health-related quality of life in Chinese patients with chronic prostatitis/chronic pelvic pain syndrome. Qual Life Res 19, 1273–1283 (2010). https://doi.org/10.1007/s11136-010-9697-2

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