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Quality of life predicts one-year survival in patients with implantable cardioverter defibrillators

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Abstract

Purpose

This study examines the contributions of known predictors of survival and quality of life (QOL) to 1-year survival in ICD recipients.

Methods

This study used the data set from the antiarrhythmia versus implanted defibrillator (AVID) controlled clinical trial conducted by the National Institutes of Health, National Heart, Lung, and Blood Institute. The 507 patients randomly assigned to the ICD treatment were included in the analysis. Patients were mostly male (78.3%), with mean age of 64.85 ± 10.81  and mean left ventricular ejection fraction of 32.2 ± 13.45%. QOL was measured with the medical outcomes study 36-item short form health survey (SF-36) and quality of life index-cardiac version (QLI-CV). Data were analyzed with descriptive statistics and logistic regression.

Results

Fifty-four (10.6%) patients died in the first year after ICD implantation. Angiotensin-converting enzyme inhibitor (ACE) medication, age, and QLI-CV were significant independent predictors of 1-year survival. The odds of survival of a younger patient with ACE medication and good QOL were approximately three times (OR = 3.96) greater than for an older patient, without ACE medication and with poor QOL.

Conclusion

Quality of life is an important factor predicting 1-year survival in patients with ICDs. ACE medication and younger age also predict 1-year survival independent of QOL and each other.

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Abbreviations

ACE:

Angiotensin-converting enzyme inhibitor

AVID:

Antiarrhythmia Versus Implanted Defibrillator Study

CABG:

Coronary artery bypass graft

EF:

Left ventricular ejection fraction

HF:

Heart failure

ICD:

Implantable cardioverter defibrillator.

MCS:

Mental component summary score from the SF-36

NYHA:

New York Heart Association

PCS:

Physical component summary score from the SF-36

QOL:

Quality of life

QLI-CV:

Quality of life index-cardiac version

SCD:

Sudden cardiac death

SF-36:

Medical outcomes study 36-item short form health survey

VF:

Ventricular fibrillation

VT:

Ventricular tachycardia

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Acknowledgments

The antiarrhythmia versus implantable defibrillators (AVID) is conducted and supported by the NHLBI in collaboration with the AVID Study Investigators. This manuscript was prepared using a limited access data set obtained from the NHLBI and does not necessarily reflect the opinions or views of the AVID or the NHLBI.

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Authors and Affiliations

  1. National Defense Medical Center School of Nursing, Taipei, Taiwan

    Chi-Wen Kao

  2. University of Maryland School of Nursing, 655 W. Lombard Street, Baltimore, MD, 21201, USA

    Erika Friedmann & Sue A. Thomas

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  1. Chi-Wen Kao
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Correspondence to Sue A. Thomas.

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Kao, CW., Friedmann, E. & Thomas, S.A. Quality of life predicts one-year survival in patients with implantable cardioverter defibrillators. Qual Life Res 19, 307–315 (2010). https://doi.org/10.1007/s11136-010-9596-6

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