Abstract
The OVIS study is a population-based study that aims at evaluating medical care in Schleswig-Holstein (Germany). In this paper, the health related quality of life (QoL, EORTC QLQ-C30 and -BR23) of 1,927 women with breast cancer is reported. The global health status/QoL score was comparable to reference data of the age-adjusted German general population, but clinical meaningful differences (≥ 10 points) were found for all functioning scales (with the exception of physical functioning) and for three of the symptom scales/items (fatigue, dyspnoe, insomnia) with OVIS patients showing more deficits. Furthermore, OVIS patients scored higher on the item financial difficulties. Logistic regression analyses revealed that coming from an urban surrounding, having a higher social status and attendance to a regular aftercare predicted a good overall QoL, while factors that were related to perceived complications in the course of the therapy raised the risk for a low QoL rating. It is of interest, that attendance to a rehabilitation and interest in self-help groups independently predicted an increased risk for a low quality of life. Overall, we assume the global QoL is rating slightly too optimistic since major deficits were reported on the specific physical and functional scales/items.
Similar content being viewed by others
References
Aranda, S., Schofield, P., Weih, L., Yates, P., Milne, D., Faulkner, R., & Voudouris, N. (2005). Mapping the quality of life and unmet needs of urban women with metastatic breast cancer. European Journal of Cancer Care (England), 14, 211–222.
Arndt, C., Merx, H., Stürmer, T., Stegmaier, C., Ziegler, H., & Brenner, H. (2004). Age-specific detriments to quality of life among breast cancer patients one year after diagnosis. European Journal of Cancer, 40, 673–680.
Bernhard, J., Huerny, C., Maybach, R., Herrmann, R., & Laffer, U. (1999). Quality of life as a subjective experience: Reframing of perception in patients with colon cancer undergoing radical resection with or without adjuvant chemotherapy. Swiss Group for Clinical cancer Research (SAKK). Annals of Oncol, 10, 775–782.
Bernhard, J., Lowy, A., Maibach, R., & Huerny, C. (2001). Response shift in the perception of health for utility evaluation. An explorative investigation. European Journal of Cancer, 37, 1729–1735.
Bottomley, A., Therasse, P., Piccart, M., Efficace, F., Coens, C., Gotay, C., Welnicka-Jaskiewicz, M., Mauriac, L., Dyczka, J., Cufer, T., Lichinitser, M. R., Schornagel, J. H., Bonnefoi, H., & Shepherd, L. (2005). European Organisation for Research and Treatment of Cancer Breast Cancer Group; National Cancer Institute of Canada; Swiss Group for Clinical Cancer Research. Health-related quality of life in survivors of locally advanced breast cancer: An international randomised controlled phase III trial. Lancet Oncology, 6, 287–294.
Cocquyt, V. F., Blondeel, P. N., Depypere, H. T., Van De Sijpe, K. A., Daems, K. K., Monstrey, S. J., & Van Belle, S. J. (2003). Better cosmetic results and comparable quality of life after skin-sparing mastectomy and immediate autologous breast reconstruction compared to breast conservative treatment. British Journal of Plastic Surgery, 56, 462–470.
Deck, R., Roeckelein, E. (1999). Zur Erhebung soziodemographischer und sozialmedizinischer Indikatoren in den rehabilitationswissenschaftlichen Forschungsverbünden. In Verband Deutscher Rentenversicherungsträger (Eds.), DRV-Schriften Band 16: Foerderschwerpunkt “Rehabilitationswissenschaften” Empfehlungen der Arbeitsgruppen “Generische Methoden”, “Routinedaten und Reha-OEkonomie”. Heusenstamm: Central-Druck Trost GmbH & Co., 84–96.
Engel, J., Kerr, J., Schlesinger-Raab, A., Eckel, R., Sauer, H., & Hoelzel, D. (2003). Predictors of quality of life of breast cancer patients. Acta Oncologica, 42, 710–718.
Engel, J., Kerr, J., Schlesinger-Raab, A., Sauer, H., & Hoelzel, D. (2004). Quality of life following breast-conserving therapy or mastectomy: Results of a 5-year prospective study. The Breast Journal, 10, 223–231.
Fayers, P. M., Aaronson, N. K., Bjordal, K., Groenvold, M., Curran, D., & Bottomley, A. (2001). On behalf of the EORTC quality of life group. The EORTC QLQ-C30 scoring manual (3rd edn.). Brussels: European Organization for Research and Treatment of Cancer.
Ganz, P. A., Schag, A. C., Lee, J. J., Polinsky, M. L., & Tan, S. J. (1992). Breast conservation versus mastectomy. Is there a difference in psychological adjustment or quality of life in the year after surgery? Cancer, 69, 1729–1738.
Giersiepen, K., Heitmann, C., Janhsen K., & Lange, C. (2005). Gesundheitsberichterstattung des Bundes, Heft 25: Brustkrebs, Robert-Koch-Institut (Hrsg.); Berlin: Oktoberdruck.
Gulbrandsen, N., Hjermstad, M. J., & Wisloff, F. (2004). For the Nordic Myeloma study Group: Interpretation of quality of life scores in multiple myeloma by comparison with a reference population and assessment of the clinical importance of score differences. European Journal of Haematology, 72, 172–180.
Hakamies-Blomquist, L., Louma, M. L., Sjoestroem, J., Pluzanska, A., Sjoedin, M., Mouridsen, H., Ostenstad, B., Mjaaland, I., Ottosson, S., Bergh, J., Malmstroem, P. O., & Blomquist, C. (2001). Timing of quality of life (QoL) assessments as a source of error in oncological trails. Journal of Advanced Nursing, 35, 709–716.
Helgeson, V. S., & Tomich, P. L. (2005). Surviving cancer: A comparison of 5-year disease-free breast cancer survivors with healthy women. Psychooncology, 14, 307–317.
Hjermstad, M. J., Fayers, P. M., Bjordal, K., & Kaasa, S. (1998). Using reference data on quality of life—the importance of adjusting for age and gender, exemplified by the EORTC QLQ-C30 (+3). European Journal of Cancer, 34, 1381–1389.
Institut für Krebsepidemiologie e.V. Krebs in Schleswig-Holstein. Band 5: Inzidenz und Mortalität im Jahr 2003 [Institute for Cancer Epidemiology e.V. Cancer in Schleswig-Holstein. Volume 5: Incidence and mortality in the year 2003.] Lübeck: Schmidt-Roemhild 2005.
Irvine, D., Brown, B., Crooks, D., Roberts, J., & Browne, G. (1991). Psychosocial adjustment in women with breast cancer. Cancer, 67, 1097–1117.
Janni, W., Rjosk, D., Dimpfl, T. H., Haertl, K., Strobl, B., Hepp, F., Hanke, A., Bergauer, F., & Sommer, H. (2001). Quality of life influenced by primary surgical treatment for stage I–III breast cancer-long-term follow-up of a matched-pair analysis. Annals of surgical oncology, 8, 542–548.
Joly, F., Espie, M., Marty, M., Heron, J. F., & Henry-Amar, M. (2000). Long-term quality of life in premenopausal women with node-negative localized breast cancer treated with or without adjuvant chemotherapy. British Journal of Cancer, 83, 577–582.
King, M. T., Kenny, P., Shiell, A., Hall, J., & Boyages, J. (2000). Quality of life three months and one year after first treatment for early stage breast cancer: Influence of treatment and patient characteristics. Quality of Life Research, 9, 789–800.
Landesraumordnungsplan Schleswig-Holstein, (1998). Herausgegeben von der Ministerpräsidentin des Landes Schleswig-Holstein.
Osoba, D., Rodrigues, G., Myles, J., Myles, J., Zee, B., & Pater, J. (1998). Interpreting the significance of changes in health-related quality of life scores. Journal of Clinical Oncology, 16, 139–144.
Pozo, C., Carver, C. S., Noriega, V., Harris, S. D., Robinson, D. S., Ketcham, A. S., Legaspi, A., Moffat, F. L. Jr., & Clark, K. C. (1992). Effects of mastectomy versus lumpectomy on emotional adjustment to breast cancer: A prospective study of the first year postsurgery. Journal of Clinical Oncology, 10, 1292–1298.
Sauer, H., & Hoelzel, D. (1995). Mammakarzinom—Revision der Nachsorgeempfehlungen. Teil 2: Spezielle Aussagen zu Skelettszintigraphie, Roentgen-Thorax, Lebersonographie, Mammographie und Laboruntersuchungen. [Breast carcinoma—revision of follow-up recommendations. 2: Special diagnostic value of bone scintigraphy, thoracic radiography, liver ultrasonic, mammography and laboratory tests] Fortschr Med 113, 210–214.
Schou, I., Ekeberg, O., Sandvik, L., Hjermstad, M. J., & Ruland, C. M. (2005). Multiple predictors of health-related quality of life in early stage breast cancer. Data from a year follow-up study compared with the general population. Quality Life Research, 14, 1813–1823.
Schwarz, R., & Hinz, A. (2001). Reference data for the quality of life questionnaire EORTC QLQ-C30 in the general German population. European Journal of Cancer, 37, 1345–1351.
Stead, M. L. (2003). Sexual dysfunction after treatment for gynaecologic and breast malignancies. Current Opinion in Obstetrics & Gynecology, 15, 57–61.
Zieren, H. U., Jacobi, A., Zieren, J., & Müller, J. M. (1996). Lebensqualitäterfassung nach Resektion colorectaler Carcinome. Der Chirurg, 67, 703–709.
Acknowledgements
We would like to thank the participating patients for their engagement and for sharing their cancer stories with us. And we would like to thank Carmen Bartel, Tatjana Burkhardt-Hammer and Betty Schmidtkunz for their collaboration. Furthermore we thank Birgit Templin for organisation of the study and thank Sebastian Bellin, Stefanie Bielenberg, Joerdis Dreckschmidt, Veronika Kleps, Thomas Naumann, Nina Ritterhoff and Carolin Roessler for data entry. Funding for the OVIS study was provided by the Deutsche Krebshilfe e.V.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Waldmann, A., Pritzkuleit, R., Raspe, H. et al. The OVIS study: health related quality of life measured by the EORTC QLQ-C30 and -BR23 in German female patients with breast cancer from Schleswig-Holstein. Qual Life Res 16, 767–776 (2007). https://doi.org/10.1007/s11136-006-9161-5
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s11136-006-9161-5