Abstract
Structural equation modeling (SEM) has been widely used in psychology and sociology for testing validity of measurement instruments. However, this statistical technique has so far played minor role in quality-of-life research. The main objective of this paper is to demonstrate the potential of SEM for constructing and testing the validity of a Subjective Well-being under Neuroleptics (SWN) index for patients with schizophrenia. For these purposes, data from the GEO study (Gesundheitsökonomische Evaluation von Olanzapin in Deutschland; Health economics study of olanzapine in the treatment of schizophrenia in Germany) were used. The GEO is a prospective, comparative, noninterventional, observational study. A total of 646 participants treated with either olanzapine (n = 416) or haloperidol (n = 230) were enrolled in the study; 360 patients were available for factor analyses. The short (20-item) form of the SWN scale was administered to assess patients’ perspectives on their quality of life. The structural equation models (SEMs) were then applied to construct 5- and 10-item indexes based on SWN. The data indicate that the 5-item index is the most time-saving approach for evaluating perceptions of well-being (and thus, quality of life) among patients with schizophrenia. The application of SEM showed no appreciable loss of validity of this index.
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Abbreviations
- “p-value”:
-
p is the probability of getting as large a discrepancy as occurred with the present sample
- AGFI:
-
Adjusted Goodness-of-Fit Index
- AIC:
-
Akaike information criterion
- BCC:
-
Brown–Cudeck criterion
- BIC:
-
Bayes information criterion
- CAIC:
-
Consistent Akaike information criterion
- CFA:
-
confirmatory factor analysis
- CMIN/DF:
-
Minimum value of the discrepancy function divided by degrees of freedom
- Er:
-
emotional regulation
- Err:
-
error
- EuroQol:
-
European Quality of Life [questionnaire]
- GEO:
-
Gesundheitsökonomische Evaluation von Olanzapin in Deutschland (Health economics study of olanzapine in the treatment of schizophrenia in Germany)
- GFI:
-
goodness-of-fit index
- ICD-10:
-
International Classification of Diseases, Tenth Edition
- Mf:
-
mental functioning
- MI:
-
modification index/indices
- MLDL:
-
Munich Quality-of-Life Dimensions List
- PCLOSE:
-
“p value” for testing the null hypothesis of the close fit
- Pf:
-
physical functioning
- QoL:
-
quality of life
- res:
-
residual
- RMS:
-
root mean square error of approximation (Steiger and Lind)
- RMSEA:
-
root mean squared error of approximation (Browne and Cudeck)
- Sc:
-
self-control
- SEM:
-
structural equation model(s)
- SF-36:
-
Medical Outcomes Study 36-Item Short-Form Health Survey
- Si:
-
social integration
- SRM:
-
Social Research Methodology [database]
- SWN:
-
Subjective Well-being under Neuroleptics
- ULS:
-
unweighted least squares
- VAR:
-
variable
- VAS:
-
Visual Analogue Scale
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Schmidt, P., Clouth, J., Haggenmüller, L. et al. Constructing an Index for the Subjective Well-being Under Neuroleptics Scale (SWN), short form: Applying structural equation modeling for testing reliability and validity of the index. Qual Life Res 15, 1191–1202 (2006). https://doi.org/10.1007/s11136-006-0069-x
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DOI: https://doi.org/10.1007/s11136-006-0069-x