Abstract
Iron-deficiency anemia (IDA) is a common disease in females of childbearing age. Although iron supplementation quickly improves laboratory-measured parameters, its effect on health-related quality of life is unknown. Here, we conducted a prospective follow-up study to evaluate health-related quality of life in pre-menopausal women diagnosed with IDA. A convenience sample of 92 patients who visited Tokai University Hospital and three other affiliated hospitals were asked to fill out the Medical Outcome Study 36-item short-form health survey (SF-36) during the course of treatment (baseline, and 1 and 3 months after the start of treatment). At baseline, vitality and general health scores were significantly lower than the Japanese national norms. After the start of therapy, however, a significant improvement was seen in all domain scores except role emotional (RE), and at 3 months all eight scores were comparable to or greater than the national norms. In particular, physical functioning and vitality scores of patients with a lower hemoglobin level ( < 9.0 g/dl) at baseline showed a dramatic improvement. Iron supplementation in IDA patients improves not only hemoglobin levels, but also physical function, vitality, and general health perception.
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References
Uchida T, Yoshida M, Sakai K, et al. (1988) Prevalence of iron deficiency in Japanese women. Nippon Ketsueki Gakkai Zasshi 51:24–27
Looker AC, Dallman PR, Carroll MD, Gunter EW, Johnson CL. (1997) Prevalence of iron deficiency in the United States. JAMA 277:973–976
Haas JD, Brownlie Tt (2001) Iron deficiency and reduced work capacity: A critical review of the research to determine a causal relationship. J Nutr 131:676S–688S; discussion 688S–690S
Kasper DL, Fauci AS, Longo DL, Braunwald E (2005) Harrison’s Principles of Internal Medicine. 16 ed Columbus, OH, McGraw-Hill Co.
Ware JE Jr, Sherbourne CD (1992) The MOS 36-item short-form health survey (SF-36). I. Conceptual framework and item selection. Med Care 30:473–483
Fukuhara S, Bito S, Green J, Hsiao A, Kurokawa K, (1998) Translation, adaptation, and validation of the SF-36 Health Survey for use in Japan. J Clin Epidemiol 51:1037–1044
McHorney CA, Ware JE Jr, Raczek AE (1993) The MOS 36-Item Short-Form Health Survey (SF-36): II. Psychometric and clinical tests of validity in measuring physical and mental health constructs. Med Care 31:247–263
McHorney CA, Ware JE Jr, Lu JF, Sherbourne CD (1994) The MOS 36-item Short-Form Health Survey (SF-36): III. Tests of data quality, scaling assumptions, and reliability across diverse patient groups. Med Care 32:40–66
Fukuhara S, Ware JE Jr, Kosinski M, Wada S, Gandek B (1998) Psychometric and clinical tests of validity of the Japanese SF-36 Health Survey. J Clin Epidemiol. 51:1045–1053
Diggle PJ, Heagerty P, Liang KY, Aeger SL (2002) Analysis of Longitudinal Data. 2nd ed Oxford, Oxford University Press
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Address for correspondence: Kiyoshi Ando, Department of Hematology and Oncology, Tokai University School of Medicine, Bohseidai, Isehara, Kanagawa 259-1193, Japan Phone: +81-463-93-1121; Fax: +81-463-92-4511 E-mail: andok@keyaki.cc.u-tokai.ac.jp
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Ando, K., Morita, S., Higashi, T. et al. Health-Related Quality of Life Among Japanese Women With Iron-Deficiency Anemia. Qual Life Res 15, 1559–1563 (2006). https://doi.org/10.1007/s11136-006-0030-z
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DOI: https://doi.org/10.1007/s11136-006-0030-z