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Measuring the Impact of Diabetes Through Patient Report of Treatment Satisfaction, Productivity and Symptom Experience

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Abstract

Objective: Diabetes is a common, debilitating chronic illness with multiple impacts. The impact on treatment satisfaction, productivity impairment and the symptom experience may be among the most important for patient-reported outcomes. This study developed and validated disease-specific, patient-reported measures for these outcomes that address limitations in currently available measures. Methods: Data was collected from the literature, experts and patients and a conceptual model of the patient-reported impact of diabetes was created. Item pools, based on the conceptual model, were then generated. The items were administered to 991 diabetes patients via a web-based survey to perform item reduction, identify relevant factor structures and assess reliability and validity following an a-priori analysis plan. Results: All validation criteria and hypotheses were met resulting in three new, valid measures: a 21-item Satisfaction Measure (three sub-scales: burden, efficacy and symptoms), a 30-item Symptom Measure and a 14-item Productivity Measure assessing both life and work productivity impairments.Conclusion: This triad of measures captures important components of the multifaceted diabetes patient experience and can be considered as valid, viable options when choosing measures to assess patient-reported outcomes. Addressing these outcomes may assist researchers and clinicians to develop more patient-centered diabetes interventions and care.

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Abbreviations

DPM:

Diabetes Productivity Measure

DSM:

Diabetes Symptom Measure

ITAS:

Insulin Treatment Appraisal Scale

MCID:

Minimal Clinically Important Difference

OLS:

Ordinary Least Squares

PAID:

Problem Areas in Diabetes Survey

PRO:

Patient-Reported Outcomes

SAP:

Statistical Analysis Plan

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Authors and Affiliations

  1. The BROD GROUP, 219 Julia Avenue, Mill Valley, California, 94941, USA

    Meryl Brod

  2. Novo Nordisk, Bagsvaerd, Denmark

    Soren E. Skovlund & Kim U. Wittrup-Jensen

Authors
  1. Meryl Brod
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  2. Soren E. Skovlund
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  3. Kim U. Wittrup-Jensen
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Correspondence to Meryl Brod.

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Brod, M., Skovlund, S.E. & Wittrup-Jensen, K.U. Measuring the Impact of Diabetes Through Patient Report of Treatment Satisfaction, Productivity and Symptom Experience. Qual Life Res 15, 481–491 (2006). https://doi.org/10.1007/s11136-005-1624-6

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  • DOI: https://doi.org/10.1007/s11136-005-1624-6

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