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Effects of Fruit Extracts on Pancreatic Lipase Activity in Lipid Emulsions

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Abstract

Pancreatic lipase is the most important enzyme in digestion of triglycerides. Reduction of energy intake from dietary fat through inhibition of this enzyme may be a strategy to prevent and treat obesity. In this study, the effect of 31 fruit extracts on pancreatic lipase was investigated using triolein, sunflower oil and rapeseed oil emulsions. Surprisingly, about 30 % of the fruits tested stimulated pancreatic lipase activity in oil emulsions by over 50 %. Only six fruit extracts were found to inhibit pancreatic lipase activity with the IC50 value varying from 21.11 to 266.48 mg of fruit equivalent/ml of emulsion. Among them, chokeberry demonstrated the highest anti-lipase activity. The inhibitory activity ranks were comparable in all lipid emulsion models and suggest that consumption of chokeberry, red gooseberry and red currant fruits may be a new dietary option for reduction of fat absorption via inhibition of pancreatic lipase.

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Acknowledgments

The work was funded by the National Science Centre, allocated on the basis of Decision No DEC-2011/01/B/NZ9/02046. The authors thank Ms. Barbara Anders for her technical support in preparing fruit extracts and students Mariola Wesołkowska, Sebastian Kmiecik and Marcin Jarzębski for their technical support during determination of lipase activity. We also thank Professor Maria Koziołkiewicz for proofreading the manuscript.

Conflict of interest

The authors declare no conflict of interest.

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This article does not contain any studies with human or animal subjects.

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Authors and Affiliations

  1. Institute of Technical Biochemistry, Faculty of Biotechnology and Food Sciences, Lodz University of Technology, Stefanowskiego 4/10, 90-924, Łódź, Poland

    Dorota Sosnowska, Anna Podsędek & Małgorzata Redzynia

  2. Institute of Chemical Food Technology, Faculty of Biotechnology and Food Sciences, Lodz University of Technology, Stefanowskiego 4/10, 90-924, Łódź, Poland

    Dorota Żyżelewicz

Authors
  1. Dorota Sosnowska
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  2. Anna Podsędek
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  3. Małgorzata Redzynia
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  4. Dorota Żyżelewicz
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Correspondence to Anna Podsędek.

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Sosnowska, D., Podsędek, A., Redzynia, M. et al. Effects of Fruit Extracts on Pancreatic Lipase Activity in Lipid Emulsions. Plant Foods Hum Nutr 70, 344–350 (2015). https://doi.org/10.1007/s11130-015-0501-x

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