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Development and Initial Testing of an mHealth Transitions of Care Intervention for Adults with Schizophrenia-Spectrum Disorders Immediately Following a Psychiatric Hospitalization

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Abstract

An important period in the care of patients with schizophrenia-spectrum disorders is when they transition from inpatient to outpatient services and are at increased risk for relapse and rehospitalization. Thus, we developed and examined the initial feasibility, acceptability, and clinical effects of an mHealth transitions of care intervention (Mobile After-Care Support; MACS) in an open trial. Ten adults with schizophrenia-spectrum disorders were recruited during their index psychiatric hospitalization and enrolled prior to discharge. Measures of feasibility, acceptability, and MACS targets were administered at baseline and a 1-month follow-up. Drawing on skills from Cognitive Behavioral Therapy for Psychosis (CBTp), MACS delivered brief assessments of clinically relevant variables, followed by just-in-time interventions for patients starting immediately post-discharge. Individuals completed about one session per day on average as expected. Overall, measures of MACS usability and satisfaction were positive. T-test analyses showed that dysfunctional coping strategies significantly decreased from baseline to 1-month follow-up. Results also revealed statistically significant reductions in psychiatric symptoms over 1-month follow-up. This study demonstrates the feasibility and acceptability of MACS, a new app-based intervention targeting transitions of care for patients with psychosis. The field is turning to the use of mobile technology as a means of augmenting service delivery and providing real-time assessment and intervention for patients at risk. MACS is a promising adjunctive intervention that warrants further testing in a randomized controlled trial.

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References

  1. Chong HY, Teoh SL, Wu DBC, Kotirum S, Chiou CF, Chaiyakunapruk N. Global economic burden of schizophrenia: a systematic review. Neuropsychiatr Dis Treat. 2016;12:357–73.

    PubMed  PubMed Central  Google Scholar 

  2. Jin HJ, Mosweu I. The societal cost of schizophrenia: a systematic review. Pharmacoeconomics. 2017;35(1):25–42.

    PubMed  Google Scholar 

  3. Global Burden of Disease Study C. Global, regional, and national incidence, prevalence, and years lived with disability for 301 acute and chronic diseases and injuries in 188 countries, 1990-2013: a systematic analysis for the global burden of disease study 2013. Lancet. 2015;386(9995):743–800.

    Google Scholar 

  4. Feki R, Feki I, Smaoui N, Baati I, Abida I, Masmoudi J, et al. The burden among caregivers of patients with chronic psychoses. Eur Psychiatry. 2015;30:1380.

    Google Scholar 

  5. Foldemo A, Gullberg M, Ek A-C, Bogren L, Linköpings U. Institutionen för nervsystem och r, et al. quality of life and burden in parents of outpatients with schizophrenia. Soc Psychiatry Psychiatr Epidemiol. 2005;40(2):133–8.

    PubMed  Google Scholar 

  6. Fulford D, Niendam TA, Floyd EG, Carter CS, Mathalon DH, Vinogradov S, et al. Symptom dimensions and functional impairment in early psychosis: more to the story than just negative symptoms. Schizophr Res. 2013;147(1):125–31.

    PubMed  PubMed Central  Google Scholar 

  7. Olfson M, Mechanic D, Hansell S, Boyer CA, Walkup J, Weiden PJ. Predicting medication noncompliance after hospital discharge among patients with schizophrenia. Psychiatr Serv. 2000;51(2):216–22.

    CAS  PubMed  Google Scholar 

  8. Kreyenbuhl J, Slade EP, Medoff DR, Brown CH, Ehrenreich B, Afful J, et al. Time to discontinuation of first- and second-generation antipsychotic medications in the treatment of schizophrenia. Schizophr Res. 2011;131(1–3):127–32.

    PubMed  PubMed Central  Google Scholar 

  9. Mullins CD, Obeidat NA, Cuffel BJ, Naradzay J, Loebel AD. Risk of discontinuation of atypical antipsychotic agents in the treatment of schizophrenia. Schizophr Res. 2008;98(1–3):8–15.

    PubMed  Google Scholar 

  10. Novick D, Haro JM, Suarez D, Perez V, Dittmann RW, Haddad PM. Predictors and clinical consequences of non-adherence with antipsychotic medication in the outpatient treatment of schizophrenia. Psychiatry Res. 2010;176(2–3):109–13.

    PubMed  Google Scholar 

  11. Kimhy D, Harkavy-Friedman JM, Nelson EA. Identifying life stressors of patients with schizophrenia at hospital discharge. Psychiatr Serv. 2004;55(12):1444–5.

    PubMed  Google Scholar 

  12. Byerly MJ, Nakonezny PA, Lescouflair E. Antipsychotic medication adherence in schizophrenia. Psychiatr Clin North Am. 2007;30(3):437–52.

    PubMed  Google Scholar 

  13. Dolder CR, Lacro JP, Leckband S, Jeste DV. Interventions to improve antipsychotic medication adherence: review of recent literature. J Clin Psychopharmacol. 2003;23(4):389–99.

    PubMed  Google Scholar 

  14. Zygmunt A, Olfson M, Boyer CA, Mechanic D. Interventions to improve medication adherence in schizophrenia. Am J Psychiatry. 2002;159(10):1653–64.

    PubMed  Google Scholar 

  15. Farhall J, Thomas N. Cognitive and behavioural therapies for psychosis. Aust Nz J Psychiat. 2013;47(6):508–11.

    Google Scholar 

  16. Farhall J, Greenwood KM, Jackson HJ. Coping with hallucinated voices in schizophrenia: a review of self-initiated strategies and therapeutic interventions. Clin Psychol Rev. 2007;27(4):476–93.

    PubMed  Google Scholar 

  17. Steel Ce. CBT for schizophrenia: evidence-based interventions and future directions. Hoboken: Wiley; 2012.

    Google Scholar 

  18. Turner DT, van der Gaag M, Karyotaki E, Cuijpers P. Psychological interventions for psychosis: a meta-analysis of comparative outcome studies. Am J Psychiatry. 2014;171(5):523–38.

    PubMed  Google Scholar 

  19. Premkumar P, Peters ER, Fannon D, Anilkumar AP, Kuipers E, Kumari V. Coping styles predict responsiveness to cognitive behaviour therapy in psychosis. Psychiatry Res. 2011;187(3):354–62.

    PubMed  PubMed Central  Google Scholar 

  20. Bolger N, Davis A, Rafaeli E. Diary methods: capturing life as it is lived. Annu Rev Psychol. 2003;54:579–616.

    PubMed  Google Scholar 

  21. Shiffman S, Stone AA, Hufford MR. Ecological momentary assessment. Annu Rev Clin Psychol. 2008;4:1–32.

    PubMed  Google Scholar 

  22. Heron KE, Smyth JM. Ecological momentary interventions: incorporating mobile technology into psychosocial and health behaviour treatments. Brit J Health Psych. 2010;15:1–39.

    Google Scholar 

  23. Graham AK, Lattie EG, Mohr DC. Experimental therapeutics for digital mental health. JAMA Psychiat. 2019;76(12):1223–4.

    Google Scholar 

  24. Alvarez-Jimenez M, Alcazar-Corcoles MA, Gonzalez-Blanch C, Bendall S, McGorry PD, Gleeson JF. Online, social media and mobile technologies for psychosis treatment: a systematic review on novel user-led interventions. Schizophr Res. 2014;156(1):96–106.

    CAS  PubMed  Google Scholar 

  25. Bell IH, Lim MH, Rossell SL, Thomas N. Ecological momentary assessment and intervention in the treatment of psychotic disorders: a systematic review. Psychiatr Serv. 2017;68(11):1172–81.

    PubMed  Google Scholar 

  26. Palmier-Claus JE, Rogers A, Ainsworth J, Machin M, Barrowclough C, Laverty L, et al. Integrating mobile-phone based assessment for psychosis into people's everyday lives and clinical care: a qualitative study. BMC Psychiatry. 2013;13.

  27. Depp CA, Mausbach B, Granholm E, Cardenas V, Ben-Zeev D, Patterson TL, et al. Mobile interventions for severe mental illness design and preliminary data from three approaches. J Nerv Ment Dis. 2010;198(10):715–21.

    PubMed  PubMed Central  Google Scholar 

  28. Granholm E, Ben-Zeev D, Link PC, Bradshaw KR, Holden JL. Mobile assessment and treatment for schizophrenia (MATS): a pilot trial of an interactive text-messaging intervention for medication adherence, socialization, and auditory hallucinations. Schizophr Bull. 2012;38(3):414–25.

    PubMed  Google Scholar 

  29. Granholm E, Loh C, Swendsen J. Feasibility and validity of computerized ecological momentary assessment in schizophrenia. Schizophr Bull. 2008;34(3):507–14.

    PubMed  Google Scholar 

  30. Swendsen J, Ben-Zeev D, Granholm E. Real-time electronic ambulatory monitoring of substance use and symptom expression in schizophrenia. Am J Psychiatr. 2011;168(2):202–9.

    PubMed  Google Scholar 

  31. Ben-Zeev D, McHugo GJ, Xie H, Dobbins K, Young MA. Comparing Retrospective Reports to Real-Time/Real-Place Mobile Assessments in Individuals With Schizophrenia and a Nonclinical Comparison Group. Schizophr Bull. 2012.

  32. Edwards CJ, Cella M, Tarrier N, Wykes T. The optimisation of experience sampling protocols in people with schizophrenia. Psychiatry Res. 2016;244:289–93.

    PubMed  Google Scholar 

  33. Moitra E, Gaudiano BA, Davis CH, Ben-Zeev D. Feasibility and acceptability of post-hospitalization ecological momentary assessment in patients with psychotic-spectrum disorders. Compr Psychiatry. 2017;74:204–13.

    PubMed  PubMed Central  Google Scholar 

  34. Ben-Zeev D, Scherer EA, Gottlieb JD, Rotondi AJ, Brunette MF, Achtyes ED, et al. mHealth for schizophrenia: patient engagement with a Mobile phone intervention following hospital discharge. JMIR Ment Health. 2016;3(3):e34.

    PubMed  PubMed Central  Google Scholar 

  35. Pijnenborg GHM, Withaar FK, Brouwer WH, Timmerman ME, van den Bosch RJ, Evans JJ. The efficacy of SMS text messages to compensate for the effects of cognitive impairments in schizophrenia. Brit J Clin Psychol. 2010;49:259–74.

    CAS  Google Scholar 

  36. Ben-Zeev D, Brenner CJ, Begale M, Duffecy J, Mohr DC, Mueser KT. Feasibility, acceptability, and preliminary efficacy of a smartphone intervention for schizophrenia. Schizophr Bull. 2014;40(6):1244–53.

    PubMed  PubMed Central  Google Scholar 

  37. Bell IH, Rossell SL, Farhall J, Hayward M, Lim MH, Fielding-Smith SF, et al. Pilot randomised controlled trial of a brief coping-focused intervention for hearing voices blended with smartphone-based ecological momentary assessment and intervention (SAVVy): feasibility, acceptability and preliminary clinical outcomes. Schizophr Res. in press.

  38. First MB, Williams JBW, Karg RS, Spitzer RL. Structured clinical interview for DSM-5—research version (SCID-5 for DSM-5, research version; SCID-5-RV). Arlington: American Psychiatric Association; 2015.

    Google Scholar 

  39. Wenze SJ, Gaudiano BA, Weinstock LM, Tezanos KM, Miller IW. Adjunctive psychosocial intervention following hospital discharge for patients with bipolar disorder and comorbid substance use: a pilot randomized controlled trial. Psychiatry Res. 2015;228(3):516–25.

    PubMed  PubMed Central  Google Scholar 

  40. Larsen D, Attkisson C, Hargreaves W, Nguyen T. Assessment of client/patient satisfaction: development of a general scale. Eval Program Plann. 1979;2:197–207.

    CAS  PubMed  Google Scholar 

  41. Attkisson C, Zwick R. The client satisfaction questionnaire: psychometric properties and correlations with service utilization and psychotherapy outcome. Eval Program Plann. 1982;5(3):233–7.

    CAS  PubMed  Google Scholar 

  42. Brooke J. SUS-A quick and dirty usability scale. Usabil Eval Industr. 1996;194:4–7.

    Google Scholar 

  43. Bangor A, Kortum PT, Miller JT. An empirical evaluation of the system usability scale. Int J Hum-Comput Int. 2008;24(6):574–94.

    Google Scholar 

  44. Lund AM. Measuring usability with the use questionnaire. Usability Interface. 2001;8(2):3–6.

    Google Scholar 

  45. Gao M, Kortum P, Oswald F. Psychometric evaluation of the USE (usefulness, satisfaction, and ease of use) questionnaire for reliability and validity proceedings of the human factors and ergonomics society. Annual Meeting. 2018;2018:1414–8.

    Google Scholar 

  46. Martins MJRV, Pinto AM, Castilho P, Macedo AF, Pereira AT, Bajouco M, et al. Assessing beliefs and attitudes towards antipsychotic medication from a recovery-based perspective: psychometric properties of a new scale. Psychiatry Res. 2019;273:325–30.

    PubMed  Google Scholar 

  47. Byerly MJ, Nakonezny PA, Rush AJ. The brief adherence rating scale (BARS) validated against electronic monitoring in assessing the antipsychotic medication adherence of outpatients with schizophrenia and schizoaffective disorder. Schizophr Res. 2008;100(1–3):60–9.

    PubMed  Google Scholar 

  48. Carver CS. You want to measure coping but your protocol's too long: consider the brief COPE. Int J Behav Med. 1997;4(1):92–100.

    CAS  PubMed  Google Scholar 

  49. Coolidge FL, Segal DL, Hook JN, Stewart S. Personality disorders and coping among anxious older adults. J Anxiety Disord. 2000;14(2):157–72.

    CAS  PubMed  Google Scholar 

  50. Ventura J, Lukoff D, Nuechteriein K, Liberman RP, Green MF, Shaner A. Brief psychiatric rating scale (BPRS): Expanded Version, Ver. 4.0. 1993.

  51. Mueser KT, Curren PJ, McHugo GJ. Factor structure of the brief psychiatric rating scale in schizophrenia. Psychol Assess. 1997;9(3):196–204.

    Google Scholar 

  52. WHO. Measuring Health and Disability: Manual for WHO Disability Assessment Schedule (WHODAS 2.0)2010.

  53. McKibbin C, Patterson TL, Jeste DV. Assessing disability in older patients with schizophrenia - results from the WHODAS-II. J Nerv Ment Dis. 2004;192(6):405–13.

    PubMed  Google Scholar 

  54. Oorschot M, Lataster T, Thewissen V, Lardinois M, Wichers M, van Os J, et al. Emotional experience in negative symptoms of schizophrenia-no evidence for a generalized hedonic deficit. Schizophr Bull. 2013;39(1):217–25.

    PubMed  Google Scholar 

  55. Ben-Zeev D, Ellington K, Swendsen J, Granholm E. Examining a cognitive model of persecutory ideation in the daily life of people with schizophrenia: a computerized experience sampling study. Schizophr Bull. 2011;37(6):1248–56.

    PubMed  Google Scholar 

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Correspondence to Ethan Moitra.

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Moitra, E., Park, H.S. & Gaudiano, B.A. Development and Initial Testing of an mHealth Transitions of Care Intervention for Adults with Schizophrenia-Spectrum Disorders Immediately Following a Psychiatric Hospitalization. Psychiatr Q 92, 259–272 (2021). https://doi.org/10.1007/s11126-020-09792-9

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