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Comorbid Anxiety in Bipolar Disorder Alters Treatment and Prognosis

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Abstract

Mood disorders in general, and bipolar disorder in particular, are unique among the psychiatric conditions in that they are associated with extraordinarily high rates of comorbidity with a multitude of psychiatric and medical conditions. Among all the potential cormobidities, co-occurring anxiety disorders stand out due to their very high prevalence. Outcome in bipolar illness is worse in the presence of a comorbid anxiety disorder. The coexistence of an anxiety disorder presents a particularly difficult challenge in the treatment of bipolar illness since antidepressants, the mainstay of pharmacologic treatments for anxiety, may adversely alter the course of manic-depression. Identification of anxiety disorders in bipolar patients is important. The treatment plan needs to balance the potential benefit and harm of antidepressant administration.

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Authors and Affiliations

  1. Department of Psychiatry and Behavioral Sciences, University of Louisville School of Medicine, MedCenter One, 501 E Broadway, Suite 340, Louisville, KY, 40202, USA

    Rif S. El-Mallakh

  2. Behavioral Health Research Center of the Southwest (BHRCS), A Center of the Pacific Institute for Research and Evaluation (PIRE), 612 Encino Place, N.E., Albuquerque, NM, 87102, USA

    Michael Hollifield

  3. Institute for Stress Medicine, Albuquerque, NM, USA

    Michael Hollifield

  4. Department of Psychiatry, University of Louisville School of Medicine, Louisville, KY, USA

    Michael Hollifield

  5. Family Medicine, University of New Mexico, 612 Encino Place, N.E., Albuquerque, NM, 87102, USA

    Michael Hollifield

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  1. Rif S. El-Mallakh
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Correspondence to Rif S. El-Mallakh.

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El-Mallakh, R.S., Hollifield, M. Comorbid Anxiety in Bipolar Disorder Alters Treatment and Prognosis. Psychiatr Q 79, 139–150 (2008). https://doi.org/10.1007/s11126-008-9071-5

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