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Metabolic syndrome and its components in adult hypopituitary patients

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Abstract

Purpose

To evaluate the prevalence of metabolic syndrome (MetS) and its components in adult hypopituitary patients.

Patients and methods

Retrospective, cross-sectional analysis of a cohort of hypopituitary adult patients followed in a single reference center for pituitary diseases. MetS was defined by the National Cholesterol Education Program Adult Treatment Panel III (NCEP-ATP III) criteria. Patients with 18 years or older, presenting two or more anterior pituitary deficiencies associated or not with diabetes insipidus (DI), were included, while patients with hypopituitarism due to Acromegaly or Cushing’s disease were excluded.

Results

We studied 99 hypopituitary patients (52 males, mean age 50.1 ± 16.3 years, mean age at diagnosis 33.7 ± 17.6 years) who have been followed for a mean time of 15.9 ± 10.1 years. Hypothalamic-pituitary tumors and non-tumoral etiologies were observed in 53.4% and 46.6% of the cases, respectively. FSH/LH, GH, TSH, ACTH deficiency and DI was present in 99%, 98.6%, 96%, 81.8%, and 23.2%, respectively. The prevalence of MetS was 39.4% and was significantly higher in patients older than 50 years (p = 0.02), overweight/obese (p < 0.001), with hypopituitarism diagnosed in adult life (p = 0.02), who did not replace GH (p = 0.004) and in smokers (p = 0.007). In the logistic regression model, body mass index (BMI) and GH replacement were significantly associated with the presence of MetS. Reduced HDL cholesterol was the most prevalent component of MetS in hypopituitary patients.

Conclusions

MetS is a common finding in adult hypopituitary patients, which is mainly influenced by increased BMI and untreated GH deficiency.

Trial Registration number (Plataforma Brasil): CAAE 51008815.2.0000.0096 (May 31, 2017) .

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Funding

The authors received no financial support for the research, authorship, and/or publication of this article.

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Authors and Affiliations

  1. Center for Health Science, Medical School, Federal University of Parana, Curitiba, Brazil

    Simone Yae Abe, Kamila Souza dos Santos, Bruna Fernanda Battistuzzi Barbosa, Claudia Maria Perera Biondo, Débora Takito, Sayuri Kuhnen Hayashi & Victor Galvani Vianna Amarilla

  2. Research Group of Exercise Medicine, Department of Integrative Medicine, Federal University of Parana, Curitiba, Brazil

    Anderson Zampier Ulbrich

  3. SEMPR (Endocrine Division), Department of Internal Medicine, Federal University of Parana, Curitiba, Brazil

    Cesar Luiz Boguszewski

  4. Serviço de Endocrinologia e Metabologia do Hospital de Clínicas da Universidade Federal do Paraná, Agostinho Leão Junior 285, Curitiba, PR, 80030-110, Brazil

    Cesar Luiz Boguszewski

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  1. Simone Yae Abe
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  2. Kamila Souza dos Santos
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Correspondence to Cesar Luiz Boguszewski.

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Abe, S.Y., dos Santos, K.S., Barbosa, B.F.B. et al. Metabolic syndrome and its components in adult hypopituitary patients. Pituitary 23, 409–416 (2020). https://doi.org/10.1007/s11102-020-01048-w

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