Abstract
Arthropathy is an invalidating complication of acromegaly. This arthropathy deteriorates radiographically despite long-term disease control. However, the clinical course and its relationship to the radiographic course are currently unknown. We aimed to investigate the clinical course of arthropathy during follow-up and its relationship to radiographic progression in long-term controlled acromegaly patients. Prospective follow-up study. We studied 58 patients (mean age 62 years, women 41 %) with controlled acromegaly for a mean of 17.6 years. Clinical progression of joint disease was defined at baseline and after 2.6 years, by the Western Ontario McMaster Universities Osteoarthritis Index (WOMAC) and Australian/Canadian Osteoarthritis Index (AUSCAN) questionnaires for lower limb and hand OA, respectively, and performance tests. Potential risk factors for progression were assessed. The clinical course of arthropathy was related to the radiographic course. On average, hand and lower limb function deteriorated during follow-up, despite large interindividual variations. Joint pain was stable over time. High levels of pain and functional impairment at baseline were related to clinical progression of hand pain and functional limitations. High baseline BMI was a risk factor for functional deterioration in the lower limb. The changes in symptoms and radiographic progression during follow-up were not related. In treated acromegaly patients, joint function deteriorates during prolonged follow-up, despite biochemical disease control, although there was interindividual variation. Clinical and radiographic course of arthropathy were not related. Therefore, in clinical practice, a combination of clinical and radiographic assessment is necessary to evaluate the course of acromegalic arthropathy.
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Biermasz NR, Pereira AM, Smit JW, Romijn JA, Roelfsema F (2005) Morbidity after long-term remission for acromegaly: persisting joint-related complaints cause reduced quality of life. J Clin Endocrinol Metab 90(5):2731–2739
Barkan A (1997) Acromegalic arthropathy and sleep apnea. J Endocrinol 155(Suppl 1):S41–S44
Wassenaar MJ, Biermasz NR, Bijsterbosch J et al (2011) Arthropathy in long-term cured acromegaly is characterised by osteophytes without joint space narrowing: a comparison with generalised osteoarthritis. Ann Rheum Dis 70(2):320–325
Wassenaar MJ, Biermasz NR, Biermasz NR, Van DN et al (2009) High prevalence of arthropathy, according to the definitions of radiological and clinical osteoarthritis, in patients with long-term cure of acromegaly: a case-control study. Eur J Endocrinol 160(3):357–365
Wassenaar MJ, Biermasz NR, Kloppenburg M et al (2010) Clinical osteoarthritis predicts physical and psychological QoL in acromegaly patients. Growth Horm IGF Res 20(3):226–233
Claessen KM, Ramautar SR, Pereira AM et al (2012) Progression of acromegalic arthropathy despite long-term biochemical control: a prospective, radiological study. Eur J Endocrinol 167(2):235–244
Biermasz NR, Dekker FW, Pereira AM et al (2004) Determinants of survival in treated acromegaly in a single center: predictive value of serial insulin-like growth factor I measurements. J Clin Endocrinol Metab 89(6):2789–2796
Biermasz NR, van DH, Roelfsema F (2000) Ten-year follow-up results of transsphenoidal microsurgery in acromegaly. J Clin Endocrinol Metab 85(12):4596–4602
Roelfsema F, van DH, Frolich M (1985) Long-term results of transsphenoidal pituitary microsurgery in 60 acromegalic patients. Clin Endocrinol (Oxf) 23(5):555–565
van der Klaauw AA, Kars M, Biermasz NR et al (2008) Disease-specific impairments in quality of life during long-term follow-up of patients with different pituitary adenomas. Clin Endocrinol (Oxf) 69(5):775–784
Bellamy N, Buchanan WW, Goldsmith CH, Campbell J, Stitt LW (1988) Validation study of WOMAC: a health status instrument for measuring clinically important patient relevant outcomes to antirheumatic drug therapy in patients with osteoarthritis of the hip or knee. J Rheumatol 15(12):1833–1840
Bellamy N, Campbell J, Haraoui B et al (2002) Clinimetric properties of the AUSCAN Osteoarthritis Hand Index: an evaluation of reliability, validity and responsiveness. Osteoarthr Cartil 10(11):863–869
Bourbonnais D, Frak V, Pilon JF, Goyette M (2008) An instrumented cylinder measuring pinch force and orientation. J Neuroeng Rehabil 5:2
Sancho-Bru JL, Giurintano DJ, Perez-Gonzalez A, Vergara M (2003) Optimum tool handle diameter for a cylinder grip. J Hand Ther 16(4):337–342
Peterfy C, Li J, Zaim S et al (2003) Comparison of fixed-flexion positioning with fluoroscopic semi-flexed positioning for quantifying radiographic joint-space width in the knee: test-retest reproducibility. Skeletal Radiol 32(3):128–132
Altman RD, Hochberg M, Murphy WA Jr, Wolfe F, Lequesne M (1995) Atlas of individual radiographic features in osteoarthritis. Osteoarthr Cartil 3 Suppl A:3–70
Bellamy N, Wilson C (2007) International estimation of minimally clinically important improvement (MCII75): the Reflect Study. Intern Med J 37:A36
Ehrich EW, Davies GM, Watson DJ, Bolognese JA, Seidenberg BC, Bellamy N (2000) Minimal perceptible clinical improvement with the Western Ontario and McMaster Universities osteoarthritis index questionnaire and global assessments in patients with osteoarthritis. J Rheumatol 27(11):2635–2641
Bruynesteyn K, Boers M, Kostense P, der Van LS, der Van HD (2005) Deciding on progression of joint damage in paired films of individual patients: smallest detectable difference or change. Ann Rheum Dis 64(2):179–182
Cole TJ, The LMS (1990) Method for constructing normalized growth standards. Eur J Clin Nutr 44(1):45–60
Rikken B, van DJ, Rikken B, Ringeling A, Massa G, Wit JM, Van den Brande JL (1998) Plasma levels of insulin-like growth factor (IGF)-I, IGF-II and IGF-binding protein-3 in the evaluation of childhood growth hormone deficiency. Horm Res 50(3):166–176
Biermasz NR, van Thiel SW, Pereira AM et al (2004) Decreased quality of life in patients with acromegaly despite long-term cure of growth hormone excess. J Clin Endocrinol Metab 89(11):5369–5376
Okazaki K, Jingushi S, Ikenoue T et al (1999) Expression of insulin-like growth factor I messenger ribonucleic acid in developing osteophytes in murine experimental osteoarthritis and in rats inoculated with growth hormone-secreting tumor. Endocrinology 140(10):4821–4830
Barkan AL (2001) Acromegalic arthropathy. Pituitary 4(4):263–264
Bijsterbosch J, Watt I, Meulenbelt I, Rosendaal FR, Huizinga TW, Kloppenburg M (2011) Clinical and radiographic disease course of hand osteoarthritis and determinants of outcome after 6 years. Ann Rheum Dis 70(1):68–73
Riyazi N, Meulenbelt I, Kroon HM et al (2005) Evidence for familial aggregation of hand, hip, and spine but not knee osteoarthritis in siblings with multiple joint involvement: the GARP study. Ann Rheum Dis 64(3):438–443
Botha-Scheepers S, Watt I, Rosendaal FR, Breedveld FC (2008) Hellio le Graverand MP, Kloppenburg M. Changes in outcome measures for impairment, activity limitation, and participation restriction over 2 years in osteoarthritis of the lower extremities. Arthritis Rheum 59(12):1750–1755
Botha-Scheepers S, Riyazi N, Watt I et al (2009) Progression of hand osteoarthritis over 2 years: a clinical and radiological follow-up study. Ann Rheum Dis 68(8):1260–1264
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Claessen, K.M.J.A., Ramautar, S.R., Pereira, A.M. et al. Increased clinical symptoms of acromegalic arthropathy in patients with long-term disease control: a prospective follow-up study. Pituitary 17, 44–52 (2014). https://doi.org/10.1007/s11102-013-0464-6
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DOI: https://doi.org/10.1007/s11102-013-0464-6