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The expression of interleukin (IL)-17 and IL-17 receptor and MMP-9 in human pituitary adenomas

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Abstract

The IL-17 plays a crucial role in the invasion of tumors. However, the effects of IL-17 on the invasion of human pituitary adenomas are still unknown. The current study is designed to investigate the possible involvement of IL-17 in the invasion of adenomas. By collecting invasive and non-invasive pituitary adenomas, the mRNA and protein levels of IL-17, IL-17R and MMP-9 are investigated. The results obtained from IHC showed that the strong positive rate and the total positive rate of IL-17, IL-17R and MMP-9 expression cells in the non-invasive group were 17.1 and 51.43%, 14.3 and 54.3%, 17.1 and 57.1%, respectively. In contrast, the strong positive rate and the total positive rate of the invasive group were significantly higher than that of the non-invasive group, which were 37.5 and 82.5%, 52.5 and 87.5%, 67.5 and 92.5%, respectively. Meanwhile, the serum IL-17 level in the invasive pituitary adenomas patients was significantly higher than in the non-invasive groups (P < 0.05). Furthermore, the mRNA levels of IL-17, IL-17R and MMP-9 were also higher in the invasive group than in the non-invasive group with statistical differences (P < 0.05), and where the expression levels of IL-17 and IL-17R had positive correlation with that of MMP-9 in the invasive group. These results suggested that IL-17 may promote the invasion of pituitary adenomas.

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Acknowledgments

We thank Feiyan Chen for providing cryoconserved serum from patients, this work was supported by the department of Pharmacology from Jiangxi Medical College.

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Authors and Affiliations

  1. Department of Neurosurgery, The First Affiliated Hospital of Sun Yat-Sen University, 510080, Guangzhou, People’s Republic of China

    Lubin Qiu, Dongsheng He, Chuangxin Liao & Haijun Wang

  2. Department of Histoembryology, Faculty of Medicine science, Sun Yat-Sen University, 510080, Guangzhou, People’s Republic of China

    Yonghong Zhu

  3. Department of Neurosurgery, The Firth Affiliated Hospital of Sun Yat-Sen University, 519000, Guangzhou, People’s Republic of China

    Xiang Fan

  4. Department of Pathology, The First Affiliated Hospital of Sun Yat-Sen University, 510080, Guangzhou, People’s Republic of China

    Zhi Li

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  1. Lubin Qiu
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Correspondence to Yonghong Zhu or Haijun Wang.

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Qiu, L., He, D., Fan, X. et al. The expression of interleukin (IL)-17 and IL-17 receptor and MMP-9 in human pituitary adenomas. Pituitary 14, 266–275 (2011). https://doi.org/10.1007/s11102-011-0292-5

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