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Volatile halogenated metabolites from marine red algae

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Abstract

A significant number of halogenated low molecular weight metabolites have exhibited an impressive array of biological properties ranging from antimicrobial to insecticidal activities. Studies on the natural products chemistry of the red seaweeds were recently stimulated by the discovery of the acyclic monoterpene halomon, which exhibits selective antitumor activity in the National Cancer Institute’s human tumor and disease oriented in vitro screen.

The present review is a taxonomy based compilation of the available literature on the halogenated volatile metabolites (C1–C10) produced by red seaweeds, with a short description of the reported ecological and pharmaceutical activities. The review begins with a presentation of simple halogenated hydrocarbons and phenols, showing their wide occurrence in rhodophyta, along with a description of simple halogenated lipids in some of the most frequently investigated red algae species and finally focuses on the chemical composition of individual red algae species.

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Authors and Affiliations

  1. Department of Pharmacy, Division of Pharmacognosy, University of Athens, Chemistry of Natural Products, 157 71, Panepistimiopolis Zografou, Athens, Greece

    Maria Kladi, Constantinos Vagias & Vassilios Roussis

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  1. Maria Kladi
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  2. Constantinos Vagias
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  3. Vassilios Roussis
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Correspondence to Vassilios Roussis.

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Dedicated to our late student Christos Varytimidis for his intuitive efforts on bioactive natural products

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Kladi, M., Vagias, C. & Roussis, V. Volatile halogenated metabolites from marine red algae. Phytochem Rev 3, 337–366 (2004). https://doi.org/10.1007/s11101-004-4155-9

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