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Quantity and quality profiles of antibiotics pre, on, and post surgery in a hospital setting

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Abstract

Background Providing proper antibiotics is undoubtedly crucial to prevent infections during surgery. Objective This study set out to evaluate the medication administration in antibiotic prophylaxis using both quantitative and qualitative methods. Setting The study employed a retrospective design and observed patients who underwent surgical procedures during hospitalization at a private hospital in Indonesia within the period of January–June 2019. Methods The data obtained were evaluated quantitatively and qualitatively; and analyzed descriptively. The quantitative evaluation used the defined daily dose (DDD) per 100 bed-days. The qualitative evaluation was expressed as the percentage of antibiotic suitability based on antibiotic administration, i.e. (1) type; (2) timing; (3) dosage; (4) duration; and (5) route. Main outcome measure Suitability of antibiotic prophylaxis in a hospital setting. Results There were 164 prescriptions recorded from 20 types of surgical procedures, of which the most common was cholecystectomy (23 patients, 14%). Most antibiotics were administered 61–120 min before the incision time (55 patients, 37%), and had a duration of more than 24 h (119 patients, 80%). The total DDD per 100 bed-days for pre-, on-, and post-surgery antibiotic use were 44.2, 33.3, and 66.7 respectively. The suitability profiles of the antibiotics used according to the Antibiotic Use Guideline for Hospital (2018) were as follows: 26.3% right type, 52.9% right time, 24.8% right dosage, 19.1% right duration, 91.8% right route, while according to American Society of Health-System Pharmacists Therapeutic Guidelines (2014) there were 17.6% right type, 53.4% right time, 16.4% right dosage, 19.1% right duration, and 96.6% right route. Conclusion Ceftriaxone was the first-choice prophylactic antibiotic administered in this Indonesian hospital. The data indicate a considerable non-compliance with local and international guidelines.

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Acknowledgements

The authors would like to thank the Director of the Private Hospital for allowing us to conduct research in their hospital. We would like to thank David Scott, Pharmacy Department, Cardiff University, UK for reviewing, editing and proofreading the manuscript.

Funding

This research received a grant from the Ministry of Research, Technology, and Higher Education of the Republic of Indonesia No. 036/SP-Lit/LPPM-01/RistekBRIN/Mono/FF/III/2020.

Conflicts of interest

The authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

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Authors and Affiliations

  1. Faculty of Pharmacy, University of Surabaya, Jl. Raya Kalirungkut, Surabaya, East Java, Indonesia, 60284

    Nurlina Muliani, Fauna Herawati & Rika Yulia

  2. Husada Utama Hospital Surabaya, Surabaya, Indonesia

    Heru Wijono

  3. Faculty of Medicine, University of Surabaya, Surabaya, Indonesia

    Heru Wijono

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  1. Nurlina Muliani
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Correspondence to Rika Yulia.

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Muliani, N., Herawati, F., Yulia, R. et al. Quantity and quality profiles of antibiotics pre, on, and post surgery in a hospital setting. Int J Clin Pharm 43, 1302–1310 (2021). https://doi.org/10.1007/s11096-021-01251-0

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