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Treatment failures secondary to drug interactions with divalent cations and fluoroquinolone

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Abstract

We observed four cases of therapeutic failures while patients were simultaneously taking medications that contained divalent cations and oral fluoroquinolones. Patients improved after conversion to the intravenous formulation of the same antibiotics, proper spacing of the divalent cation, or conversion to a different antibiotic class. Patients prescribed oral fluoroquinolones should receive instructions on proper separations of these antibiotics with divalent cations. Health care professionals should be cognizant of these interactions and educated on their potential deleterious effect.

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Authors and Affiliations

  1. Department of Clinical Sciences and Administration, University of Houston College of Pharmacy, 1441 Moursund Street, Houston, TX, 77030, USA

    K. W. Garey

  2. Metro Pharmacy Administration, Baptist Memorial Health Care, Mermphis, Tennessee, USA

    Katie J. Suda

  3. Department of Pharmacy Practice, College of Pharmacy, University of Illinois at Chicago, Chicago, Illinois, USA

    L. H. Danziger

Authors
  1. K. W. Garey
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  2. Katie J. Suda
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  3. L. H. Danziger
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Correspondence to K. W. Garey.

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Garey, K.W., Suda, K.J. & Danziger, L.H. Treatment failures secondary to drug interactions with divalent cations and fluoroquinolone. Pharm World Sci 27, 81–82 (2005). https://doi.org/10.1007/s11096-004-7040-0

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  • DOI: https://doi.org/10.1007/s11096-004-7040-0

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