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Tumor Necrosis Factor-Related Apoptosis Inducing Ligand Gene Polymorphisms are Correlated with Gastric Cancer in Central China

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Abstract

Purpose

To investigate the association of tumor necrosis factor-related apoptosis inducing ligand (TRAIL) gene polymorphisms with gastric cancer in Chinese Han population in central China.

Methods

A total of 304 patients with gastric cancer confirmed by histopathology and 421 unrelated healthy controls were studied. Gene polymorphisms of TRAIL (G1525A and C1595T) were genotyped by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis.

Results

The frequency of the genotype carriers of TRAIL 1525A (GA + AA) and 1595T (CT + TT) was significantly lower in gastric cancer than in healthy controls (37.2% vs. 61.5%, P < 0.001, OR = 0.581, 95% CI 0.442 ~ 0.764; 36.2% vs. 62.0%, P < 0.001, OR = 0.570, 95% CI 0.433 ~ 0.750, respectively). Stratification analysis showed that both TRAIL 1525A (GA + AA) and 1595T (CT + TT) carriers were associated with poorly-differentiated gastric cancer compared to 1525GG genotype and 1595CC genotype (OR = 0.516, 95%CI 0.279 ~ 0.957, P = 0.026; OR = 0.395, 95%CI 0.207 ~ 0.753, P = 0.004, respectively).

Conclusions

TRAIL G1525A and C1595T gene polymorphisms were significantly correlated with the susceptibility to gastric cancer in Chinese Han population in central China.

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Abbreviations

CI:

Confidence interval

DR:

Death receptor

EDTA:

Ethylenediamine tetraacetic acid

Hp:

Helicobacter pylori

OR:

Odds ratio

RFLP:

Restriction fragment length polymorphism-polymerase chain reaction

TIL:

Tumor-infiltrating lymphocytes

TNF:

Tumor necrosis factor

TRAIL:

Tumor necrosis factor-related apoptosis-inducing ligand

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ACKNOWLEDGMENTS AND DISCLOSURES

Changgao Wang Shufang Xu, and Fengming Yi contributed equallyto this work. This study was supported by Hubei Clinical Center & Key Laboratory of Intestinal & Colorectal Diseases (2008BCC002) and the Ministry of Public Health of China (200802156, 201002020). The authors declare that they have no competing interests.

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Authors and Affiliations

  1. Department of Gastroenterology, Zhongnan Hospital of Wuhan, University School of Medicine, Donghu Road 169, Wuhan, 430071, Hubei Province, People’s Republic of China

    Changgao Wang, Shufang Xu, Xiaobing Wang, Yuan Lei, Rui Zhou & Bing Xia

  2. Hubei Clinical Center Key Laboratory of Intestinal and Colorectal Diseases, Wuhan, 430071, People’s Republic of China

    Fengming Yi, Yuan Lei, Sha Huang, Rui Zhou & Bing Xia

Authors
  1. Changgao Wang
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  2. Shufang Xu
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  3. Fengming Yi
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  4. Xiaobing Wang
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  5. Yuan Lei
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  6. Sha Huang
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  7. Rui Zhou
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  8. Bing Xia
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Correspondence to Bing Xia.

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Wang, C., Xu, S., Yi, F. et al. Tumor Necrosis Factor-Related Apoptosis Inducing Ligand Gene Polymorphisms are Correlated with Gastric Cancer in Central China. Pharm Res 32, 762–768 (2015). https://doi.org/10.1007/s11095-013-1217-y

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  • DOI: https://doi.org/10.1007/s11095-013-1217-y

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