ABSTRACT
Purpose
To investigate mechanism of microwave enhancing drug permeation transdermally through its action on skin.
Methods
Hydrophilic pectin-sulphanilamide films, with or without oleic acid (OA), were subjected to drug release and skin permeation studies. The skins were untreated or microwave-treated, and characterized by infrared spectroscopy, Raman spectroscopy, thermal, electron microscopy and histology techniques.
Results
Skin treatment by microwave at 2450 MHz for 5 min promoted drug permeation from OA-free film without incurring skin damage. Skin treatment by microwave followed by film loaded with drug and OA resulted in permeation of all drug molecules that were released from film. Microwave exerted spacing of lipid architecture of stratum corneum into structureless domains which was unattainable by OA. It allowed OA to permeate stratum corneum and accumulate in dermis at a greater ease, and synergistically inducing lipid/keratin fluidization at hydrophobic C-H and hydrophilic O-H, N-H, C-O, C=O, C-N regimes of skin, and promoting drug permeation.
Conclusion
The microwave technology is evidently feasible for use in promotion of drug permeation across the skin barrier. It represents a new approach in transdermal drug delivery.
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ACKNOWLEDGMENTS AND DISCLOSURES
The authors wish to express heart-felt thanks to Ministry of Science, Technology and Innovation, Malaysia, and Ministry of Higher Education, Malaysia (0141903) for financial and facility support given throughout the research study.
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Wong, T.W., Nor Khaizan, A. Physicochemical Modulation of Skin Barrier by Microwave for Transdermal Drug Delivery. Pharm Res 30, 90–103 (2013). https://doi.org/10.1007/s11095-012-0852-z
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DOI: https://doi.org/10.1007/s11095-012-0852-z