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Phospholipids and Lipid-Based Formulations in Oral Drug Delivery

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ABSTRACT

Phospholipids become increasingly important as formulation excipients and as active ingredients per se. The present article summarizes particular features of commonly used phospholipids and their application spectrum within oral drug formulation and elucidates current strategies to improve bioavailability and disposition of orally administered drugs. Advantages of phospholipids formulations not only comprise enhanced bioavailability of drugs with low aqueous solubility or low membrane penetration potential, but also improvement or alteration of uptake and release of drugs, protection of sensitive active agents from degradation in the gastrointestinal tract, reduction of gastrointestinal side effects of non-steroidal anti-inflammatory drugs and even masking of bitter taste of orally applied drugs. Technological strategies to achieve these effects are highly diverse and offer various possibilities of liquid, semi-liquid and solid lipid-based formulations for drug delivery optimization.

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Authors and Affiliations

  1. Phospholipid Research Center, Im Neuenheimer Feld 582, 69120, Heidelberg, Germany

    Gert Fricker, Armin Wendel, Alfred Blume, Jürgen Zirkel, Herbert Rebmann, Constanze Setzer, Ralf-Olaf Quinkert, Frank Martin & Christel Müller-Goymann

  2. Phospholipid GmbH, Nattermannallee 1, 50829, Köln, Germany

    Torsten Kromp & Armin Wendel

  3. Institute of Pharmacy and Molecular Biotechnology, Ruprecht-Karls-University, 69120, Heidelberg, Germany

    Gert Fricker

  4. Institute of Chemistry, Martin-Luther-University, 06120, Halle, Germany

    Alfred Blume

  5. Lipoid GmbH Frigenstr. 4, 67065, Ludwigshafen, Germany

    Jürgen Zirkel, Herbert Rebmann, Constanze Setzer & Ralf-Olaf Quinkert

  6. iMEDD Inc., Columbus, OH, USA

    Frank Martin

  7. Institute of Pharmaceutical Technology, Technical University, 38106, Braunschweig, Germany

    Christel Müller-Goymann

  8. Institute of Pharmacy and Molecular Biotechnology, Im Neuenheimer Feld 366, 69120, Heidelberg, Germany

    Gert Fricker

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  1. Gert Fricker
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  2. Torsten Kromp
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  3. Armin Wendel
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  4. Alfred Blume
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  5. Jürgen Zirkel
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  6. Herbert Rebmann
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  7. Constanze Setzer
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  8. Ralf-Olaf Quinkert
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  9. Frank Martin
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  10. Christel Müller-Goymann
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Correspondence to Gert Fricker.

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Fricker, G., Kromp, T., Wendel, A. et al. Phospholipids and Lipid-Based Formulations in Oral Drug Delivery. Pharm Res 27, 1469–1486 (2010). https://doi.org/10.1007/s11095-010-0130-x

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  • DOI: https://doi.org/10.1007/s11095-010-0130-x

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