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Inner Blood-Retinal Barrier Transporters: Role of Retinal Drug Delivery

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Abstract

The inner blood-retinal barrier (inner BRB) forms complex tight junctions of retinal capillary endothelial cells to prevent the free diffusion of substances between the circulating blood and the neural retina. Thus, understanding of the inner BRB transport mechanisms could provide a basis for the development of strategies for drug delivery to the retina. Recent progress in inner BRB research has revealed that retinal endothelial cells express a variety of unique transporters which play a role in the influx transport of essential molecules and the efflux transport of xenobiotics. In this review we focus on the transport mechanism at the inner BRB in relation to its importance in influencing the inner BRB permeability of drugs.

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ACKNOWLEDGEMENT

This work was supported, in part, by a Grant-in-Aid for Scientific Research from the Japan Society for the Promotion of Science (JSPS). The authors thank Dr. M. Tomi for valuable suggestions, and S. Akanuma and T. Sugita for technical assistance.

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  1. Department of Pharmaceutics, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, 2630, Sugitani, Toyama, 930-0194, Japan

    Ken-ichi Hosoya & Masanori Tachikawa

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  1. Ken-ichi Hosoya
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Correspondence to Ken-ichi Hosoya.

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Hosoya, Ki., Tachikawa, M. Inner Blood-Retinal Barrier Transporters: Role of Retinal Drug Delivery. Pharm Res 26, 2055–2065 (2009). https://doi.org/10.1007/s11095-009-9930-2

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