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Anticancer Drug Delivery Systems Based on Curcumin Nanostructures: A Review

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Pharmaceutical Chemistry Journal Aims and scope

In recent years, the application of nanostructures in biomedical and pharmaceutical fields has increased. The special designs and compositions make nanocomposites very useful alternatives to conventional materials. Curcumin is a promising anti-cancer agent that has a positive and significant effect on chemotherapeutic achievements. The anticancer properties of curcumin have been widely investigated in different forms such as nanoparticles and nanocomposite structures. Chitosan-based nanocomposites, magnetic nanoparticles, polymer nanocomposites and blends, and montmorillonite- and alginate-based nanocomposites have been used in loading curcumin for various purposes. The anticancer preparations of curcumin nanoparticles and drug release systems employing curcumin-loaded nanoparticles, electrospun nanofibers, and hydrogel nanocomposites have been investigated. This review provides a summary of the applications of nanostructures containing curcumin, especially in controlled drug release systems. The curcumin nanoparticles and nanocomposites are suitable candidates for anticancer applications. On the nano-scale, curcumin has better aqueous solubility and, if used in a nanocomposite, there is a good ability for manipulating the drug delivery system properties.

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Acknowledgments

The authors are grateful to the University of Kashan for supporting this work.

CONDLICT OF INGTEREST

The authors declare that they have no conflict of interest.

COMPLIANCE WITH ETHICAL STANDARDS

This work did not contain any studies with human and animal subjects performed by any of the authors.

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Authors and Affiliations

  1. Department of Physical Chemistry, Faculty of Chemistry, University of Kashan, Kashan, Iran

    Zahra Mirzaie

  2. Department of Applied Chemistry, Faculty of Chemistry, University of Kashan, Kashan, Iran

    Mohammad Barati

  3. Department of Biotechnology engineering, School of Chemical Engineering, College of Engineering, University of Tehran, Tehran, Iran

    Mohammad Asadi Tokmedash

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  1. Zahra Mirzaie
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  2. Mohammad Barati
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Correspondence to Mohammad Barati.

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Mirzaie, Z., Barati, M. & Tokmedash, M.A. Anticancer Drug Delivery Systems Based on Curcumin Nanostructures: A Review. Pharm Chem J 54, 353–360 (2020). https://doi.org/10.1007/s11094-020-02203-0

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