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Engineering of Dihydroquercetin Crystals

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Pharmaceutical Chemistry Journal Aims and scope

Dihydroquercetin (DHQ) is a commercially available bioflavonoid with a wide range of pharmacological activity. The low water solubility at room temperature of the commercial drug substance limits development of DHQ-related medicines. Basic concepts of crystal engineering were used to obtain DHQ cocrystals with benzaldehyde, vanillin, cinnamaldehyde, urea, and nicotinic acid. The formation of supramolecular complexes of DHQ with the coformers was confirmed using IR spectroscopy. An estimate of the physicochemical parameters of the cocrystals established that crystal engineering was promising for obtaining new DHQ forms with improved water solubility.

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Acknowledgments

We thank Prof. N. A. Tyukavkina, Sechenov University; E. O. Bakhrushina, Head of the Pharmaceutical Technology Department, Institute of Pharmacy, Sechenov University; and Drs. M. Buchholz and D. Ramsbeck, Fraunhofer-Institute for Cell Therapy and Immunology (Germany), for assistance with performing the work and constructive advice.

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Authors and Affiliations

  1. I. M. Sechenov First Moscow State Medical University, Ministry of Health of the RF (Sechenov University), Moscow, 119991, Russia

    I. A. Selivanova & R. P. Terekhov

  2. Fraunhofer-Institut fur Zelltherapie und Immunologie, 06120, Halle (Saale), Germany

    R. P. Terekhov

Authors
  1. I. A. Selivanova
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  2. R. P. Terekhov
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Correspondence to R. P. Terekhov.

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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 53, No. 11, pp. 53 – 57, November, 2019.

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Selivanova, I.A., Terekhov, R.P. Engineering of Dihydroquercetin Crystals. Pharm Chem J 53, 1081–1085 (2020). https://doi.org/10.1007/s11094-020-02126-w

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  • DOI: https://doi.org/10.1007/s11094-020-02126-w

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