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Quantitative UV-Spectrophotometric Determination of Ribavirin

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A quantitative UV-spectrophotometric method for determining ribavirin was proposed. The method was demonstrated to be suitable in validation tests. Spectrophotometric determination of ribavirin in tablets was demonstrated to be possible.

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Acknowledgments

The work was financially supported by D. I. Mendeleev UCTR, Project Nos. 003-2018 and 013-2018.

Equipment at the Industrial Biotechnologies Common Use Center, Basic Biotechnology Principles Federal Research Center, Russian Academy of Sciences, was used for the research.

We express our sincere thanks to Profs. V. V. Kuznetsov (Department of Analytical Chemistry), V. P. Perevalov (Department of Fine Organic Synthesis and Dye Chemistry), and Yu. I. Smushkevich (Department of Organic Chemistry), D. I. Mendeleev UCTR, for discussions and assistance in interpreting the experimental results and to Senior Scientist V. V. Shubin, A. N. Bakh Biochemistry Institute, for assistance with the spectral studies and processing the obtained results.

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Authors and Affiliations

  1. D. I. Mendeleev University of Chemical Technology of Russia, 9 Miusskaya Sq., Moscow, 125047, Russia

    K. I. Kienskaya, E. V. Il’yushenko, M. V. Sardushkin, T. Yu. Koldaeva, A. M. Kusmaev, R. R. Ibragimova, I. A. Belova, A. V. Kukharenko, L. I. Shaposhnikova & G. V. Avramenko

  2. Polyclinica Virmed Ltd., 98 Boldina St., Tula, 300012, Russia

    N. Yu. Guznova

  3. Collegium Medicum, Nicolaus Copernicus University in Torun’, 13-15 Jagiellonska St., Bydgoszcz, 85067, Poland

    O. V. Zav’yalova

Authors
  1. K. I. Kienskaya
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  2. E. V. Il’yushenko
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  3. M. V. Sardushkin
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  4. N. Yu. Guznova
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  5. T. Yu. Koldaeva
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  6. A. M. Kusmaev
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  7. R. R. Ibragimova
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  8. I. A. Belova
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  9. A. V. Kukharenko
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  10. L. I. Shaposhnikova
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  11. O. V. Zav’yalova
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  12. G. V. Avramenko
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Corresponding author

Correspondence to M. V. Sardushkin.

Additional information

G. V. Avramenko is deceased.

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 53, No. 2, pp. 62 – 64, February, 2019.

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Kienskaya, K.I., Il’yushenko, E.V., Sardushkin, M.V. et al. Quantitative UV-Spectrophotometric Determination of Ribavirin. Pharm Chem J 53, 175–177 (2019). https://doi.org/10.1007/s11094-019-01974-5

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  • DOI: https://doi.org/10.1007/s11094-019-01974-5

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