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Synthesis and Antiproliferative Activity Evaluation of Aryl(Hetaryl)Cyclopentenone Analogs of Combretastatin A-4

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Pharmaceutical Chemistry Journal Aims and scope

A series of previously unreported di- and triaryl(hetaryl)cyclopentenone derivatives were prepared using a convenient synthetic method and screened preliminarily for antitumor activity in four human cell lines, i.e., T-cell leukemia (Jurkat), lung adenocarcinoma (A-549), colon cancer (HCT-116), and breast adenocarcinoma (MCF-7). The most cytotoxic of the tested compounds was 2-(3,4,5-trimethoxyphenyl)-3-(4-methoxyphenyl) cyclopent-2-en-1-one. However, it was inactive against lymphocytic leukemia P388 in mice despite its cytotoxicity in in vitro tests.

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Acknowledgments

The work was sponsored by the Russian Foundation for Basic Research (Grant 15 – 53 – 05049) and the Ministry of Education and Science of the Republic of Armenia (Grant 15RF-046) under collaborative science programs.

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Authors and Affiliations

  1. N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninskii Prosp, Moscow, 119991, Russia

    V. Z. Shirinyan & A. G. L’vov

  2. Scientific and Technological Center of Organic and Pharmaceutical Chemistry, National Academy of Sciences of Armenia, 26 Azatutyan Pr., 0014, 375014, Yerevan, Armenia

    A. I. Markosyan & S. A. Gabrielyan

  3. N. N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, 23 Kashirskoe Shosse, Moscow, 115478, Russia

    M. A. Baryshnikova

  4. D. I. Mendeleev University of Chemical Technology of Russia, 9 Miusskaya Pl., Moscow, 125047, Russia

    L. V. Yaminova

Authors
  1. V. Z. Shirinyan
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  2. A. I. Markosyan
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  3. M. A. Baryshnikova
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  4. L. V. Yaminova
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  5. A. G. L’vov
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  6. S. A. Gabrielyan
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Corresponding author

Correspondence to V. Z. Shirinyan.

Additional information

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 51, No. 10, pp. 16 – 21, October, 2017.

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Shirinyan, V.Z., Markosyan, A.I., Baryshnikova, M.A. et al. Synthesis and Antiproliferative Activity Evaluation of Aryl(Hetaryl)Cyclopentenone Analogs of Combretastatin A-4. Pharm Chem J 51, 867–872 (2018). https://doi.org/10.1007/s11094-018-1706-8

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  • DOI: https://doi.org/10.1007/s11094-018-1706-8

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