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Preparation of Inclusion Complex Between Nifedipine and Ethylenediamine-β-Cyclodextrin as Nanocarrier Agent

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Pharmaceutical Chemistry Journal Aims and scope

Nifedipine (NIF) is a poorly water-soluble and a high photosensitive drug, which is among most efficient drugs for treating diseases such as hypertension and angina pectoris. The main purpose of this work was the preparation and study of the inclusion complex between NIF and ethylenediamine-β-cyclodextrin (NIF/EDA-CD). The NIF/EDA-CD complex has been prepared using the co-precipitation method and characterized by UV-Vis spectroscopy, dynamic light scattering (DLS), differential scanning calorimetry (DSC), thermogravimetric (TGA), and Fourier-transform infrared (FT-IR) spectroscopy in both solution and solid state. The 1 : 1 molar stoichiometry is confirmed by the continuous-variation Job’s plot and phase solubility diagram. The phase solubility diagram showed a complexation constant of 1019.62 M-1. In addition, supplementary data from solubility tests have demonstrated that the solubility of NIF in water greatly increased through complexation with EDA-CD, which is a result of the water-soluble EDA-CD host.

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Acknowledgments

The authors express appreciation to the Shahid Bahonar University of Kerman Faculty Research Committee for its support of this investigation.

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Authors and Affiliations

  1. Department of Chemistry, Shahid Bahonar University of Kerman, Kerman, 76169, Iran

    Abolfazl Heydari, Mahsa Iranmanesh & Hassan Sheibani

  2. Young Researchers Society, Shahid Bahonar University of Kerman, Kerman, 76169, Iran

    Abolfazl Heydari

  3. Nutrition Department, School of Health, Kerman University of Medical Sciences, Kerman, 76169, Iran

    Farideh Doostan

Authors
  1. Abolfazl Heydari
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  2. Mahsa Iranmanesh
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  3. Farideh Doostan
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  4. Hassan Sheibani
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Correspondence to Hassan Sheibani.

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Heydari, A., Iranmanesh, M., Doostan, F. et al. Preparation of Inclusion Complex Between Nifedipine and Ethylenediamine-β-Cyclodextrin as Nanocarrier Agent. Pharm Chem J 49, 605–612 (2015). https://doi.org/10.1007/s11094-015-1338-1

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  • DOI: https://doi.org/10.1007/s11094-015-1338-1

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