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Synthesis, Toxicity, and Antituberculosis Activity of Isoniazid Derivatives Containing Sterically Hindered Phenols

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The toxicity and tuberculostatic activity of new isoniazid derivatives containing sterically hindered phenols were investigated. The investigated isoniazid derivatives exhibited lower activity and toxicity than isoniazid.

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Acknowledgments

The work was supported financially by the Russian Foundation for Basic Research (Grant 12-03-97041).

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Authors and Affiliations

  1. Kazan National Research Technological University, Kazan, Tatarstan, 420015, Russia

    Yu. N. Oludina, S. V. Bukharov, R. G. Tagasheva & G. N. Nugumanova

  2. A. E. Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Center, Russian Academy of Sciences, Kazan, Tatarstan, 420088, Russia

    A. D. Voloshina, M. V. Kulik, V. V. Zobov & A. R. Burilov

  3. Phthisiopulmonology Research Institute, Ministry of the Russian Federation for Public Health, Yekaterinburg, 620039, Russia

    M. A. Kravchenko & S. N. Skornyakov

  4. Postovsky Institute of Organic Synthesis, Ural Branch, Russian Academy of Sciences, Yekaterinburg, 620219, Russia

    G. L. Rusinov

Authors
  1. Yu. N. Oludina
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  2. A. D. Voloshina
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  3. M. V. Kulik
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  4. V. V. Zobov
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  5. S. V. Bukharov
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  6. R. G. Tagasheva
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  7. G. N. Nugumanova
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  8. A. R. Burilov
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  9. M. A. Kravchenko
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  10. S. N. Skornyakov
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  11. G. L. Rusinov
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Additional information

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 48, No. 1, pp. 8 – 10, January, 2014.

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Oludina, Y.N., Voloshina, A.D., Kulik, M.V. et al. Synthesis, Toxicity, and Antituberculosis Activity of Isoniazid Derivatives Containing Sterically Hindered Phenols. Pharm Chem J 48, 5–7 (2014). https://doi.org/10.1007/s11094-014-1032-8

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  • DOI: https://doi.org/10.1007/s11094-014-1032-8

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