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Synthesis and Antineoplastic Properties of 3-Substituted 5,5-Dimethylbenzo[h]Quinazolin-4(3H)-Ones

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Pharmaceutical Chemistry Journal Aims and scope

Ethyl 2-cyano-3,3-dimethyl-4-phenylbutanoate was cyclized into 1-amino-3,3-dimethyl-3,4-dihydronaphthalene-2-ethylcarboxylate, condensation of which with isothiocyanates synthesized 3-substituted 5,5-dimethyl-2-thioxo-2,3,5,6-tetrahydrobenzo[h]quinazolin-4(1H)-ones. The antineoplastic properties of the synthesized compounds were studied.

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References

  1. I. Sovadinova, L. Blaha, J. Janosek, K. Hilcherova, et al., Environ. Toxicol. Chem., 25(5), 1291 – 1297 (2008).

    Article  Google Scholar 

  2. B. Van Treist and G. J. Peters, Oncology, 57(3), 179 – 194 (1999).

    Article  Google Scholar 

  3. M. Hanlon and R. Ferone, Cancer Res., 56(14), 3301 – 3306 (1996).

    CAS  PubMed  Google Scholar 

  4. A. I. Markosyan, S. V. Dilanyan, S. A. Gabrielyan, et al., Khim.-farm. Zh., 44(6), 3 – 5 (2010).

    Google Scholar 

  5. A. I. Markosyan, Kh. S. Akopyan, and F. G. Arsenyan, Khim.- farm. Zh., 42(6), 7 – 11 (2008).

    Google Scholar 

  6. R. A. Kuroyan, A. I. Markosyan, M. G. Oganisyan, et al., USSR Pat. No. 1,672,728.

  7. A. I. Markosyan, S. V. Dilanyan, R. S. Sukasyan, et al., Khim.- farm. Zh., 42(3), 16 – 19 (2008).

    Google Scholar 

  8. A. I. Markosyan, S. A. Pogosyan, M. S. Safaryan, et al., Khim.-farm. Zh., 41(4), 16 – 18 (2007).

    Google Scholar 

  9. A. I. Markosyan, S. A. Pogosyan, and M. S. Safaryan, Khim. Zh. Arm., 60(3), 521 – 526 (2007).

    CAS  Google Scholar 

  10. G. N. Pershin, Methods of Experimental Chemotherapy [in Russian], Medgiz, Moscow (1971).

    Google Scholar 

  11. Z. P. Sof’ina, A. B. Syrkin, A. Goldin, et al., Experimental Assessment of Antitumor Compounds in the USSR and USA [in Russian], Meditsina, Moscow (1980).

    Google Scholar 

Download references

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Authors and Affiliations

  1. Mndjoyan Institute of Fine Organic Chemistry, Scientific and Technological Center of Organic and Pharmaceutical Chemistry, National Academy of Sciences of Armenia, Yerevan, 375014, Armenia

    A. I. Markosyan, N. M. Torshirzad, G. H. Shakhbazyan & F. G. Arsenyan

Authors
  1. A. I. Markosyan
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  2. N. M. Torshirzad
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  3. G. H. Shakhbazyan
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  4. F. G. Arsenyan
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Corresponding author

Correspondence to A. I. Markosyan.

Additional information

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 47, No. 12, pp. 29 – 32, December, 2013.

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Markosyan, A.I., Torshirzad, N.M., Shakhbazyan, G.H. et al. Synthesis and Antineoplastic Properties of 3-Substituted 5,5-Dimethylbenzo[h]Quinazolin-4(3H)-Ones. Pharm Chem J 47, 651–654 (2014). https://doi.org/10.1007/s11094-014-1025-7

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  • DOI: https://doi.org/10.1007/s11094-014-1025-7

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