Methods for the synthesis of new cyclopenta[4′,5′]pyrido[3′,2′:4,5]furo[3,2-d]pyrimidine derivatives based on 3-oxo-derivatives of cyclopenta[c]pyridines were developed. O-alkylated derivatives of these latter compounds were cyclized to furo[2,3-b]pyridines, which were converted to furo[3,2-d]pyrimidin-7-ones with formamide. Subsequent chlorination and amination of 7-oxo derivatives yielded 7-amino derivatives. The anticonvulsive and predicted tranquillizer activities of the compounds synthesized here were assessed. Compounds with anticonvulsant properties were identified.
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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 47, No. 3, pp. 8 – 11, March, 2013.
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Sirakanyan, S.N., Ovakimyan, A.A., Noravyan, A.S. et al. Synthesis and Anticonvulsive Activity of 7-Amino-Substituted Cyclopenta[4′,5′]-pyrido[3′,2′:4,5]furo[3,2-d]pyrimidines. Pharm Chem J 47, 130–134 (2013). https://doi.org/10.1007/s11094-013-0910-9
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DOI: https://doi.org/10.1007/s11094-013-0910-9