2-(1′-Hydroxy-4′-isopropenyl-1′-methylcyclohexyl-2′-thio)methylethanoate was synthesized via the reaction of (+)-1,2-limonene oxide with methylmercaptoacetate. The acute toxicity and anti-inflammatory and antipyretic activities of the starting compounds and the synthesized terpene sulfide were investigated.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
L. E. Nikitina, V. A. Startseva, I. A. Vakulenko, et al., Khim.-farm. Zh., 43(5), 20–23 (2009).
G. Sh. Isaeva and L. E. Nikitina, Helicobacter, 14(4), 404–405 (2009).
L. E. Nikitina, M. O. Anikienok, and O. N. Il’inskaya, Vestn. Tatarstan. Otd. Ross. Ekol. Akad., 1(27), 23–25 (2006).
A. Weissberger and E. S. Proskauer, Organic Solvents, 2nd Ed., rev. by J. A. Riddick and E. E. Toops, Jr., Interscience Pubs., Inc., New York (1955).
M. L. Belen’kii, Elements of Quantitative Assessment of the Pharmacological Effect [in Russian], Gos. Izd. Med. Lit., Meditsina, Leningrad (1963), pp. 121–130.
V. P. Fisenko (ed.), Handbook of Experimental (Preclinical) Study of New Drugs [in Russian], Moscow (2000), pp. 234–241.
Author information
Authors and Affiliations
Additional information
Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 46, No. 1, pp. 23 – 25, January, 2012.
Rights and permissions
About this article
Cite this article
Nikitina, L.E., Akulina, I.V., Garaev, R.S. et al. Synthesis and anti-inflammatory and antipyretic activity of 2-(1′-hydroxy-4′-isopropenyl-1′-methylcyclohexyl-2′-thio)-methylethanoate. Pharm Chem J 46, 20–22 (2012). https://doi.org/10.1007/s11094-012-0727-y
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s11094-012-0727-y