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Synthesis, antineoplastic and antimonoamineoxidase activity of 3-allyl-4-oxo-2-thioxo-1,2,3,4,5,6-hexahydrospiro(benzo[h]quinazoline-5,1'-cyclohexanes)

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Reaction of 4-amino-3-ethoxycarbonyl-1,2-dihydrospiro(naphthalene-2,1'-cyclohexane) with allylisothiocyanate was used to synthesize 3-allyl-4-oxo-2-thioxo-1,2,3,4,5,6-hexahydrospiro(benzo[h]quinazoline5,1'-cyclohexane). Condensation of the latter with halides of various structure led to a series of 2-sulfanylsubstituted benzo[h]quinazolines. The antimonoaminooxidase and antineoplastic properties of the synthesized compounds were studied.

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Acknowledgments

The work was supported financially by the International Science and Technology Center (Grant A-649).

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Authors and Affiliations

  1. Scientific and Technological Center of Organic and Pharmacological Chemistry, Mndzhoyan Institute of Fine Organic Chemistry, National Academy of Sciences of Armenia, Yerevan, Armenia

    A. I. Markosyan, S. A. Gabrielyan, F. G. Arsenyan & R. S. Sukasyan

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  1. A. I. Markosyan
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  2. S. A. Gabrielyan
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  3. F. G. Arsenyan
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  4. R. S. Sukasyan
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Additional information

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 44, No. 8, pp.3–6, August, 2010.

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Markosyan, A.I., Gabrielyan, S.A., Arsenyan, F.G. et al. Synthesis, antineoplastic and antimonoamineoxidase activity of 3-allyl-4-oxo-2-thioxo-1,2,3,4,5,6-hexahydrospiro(benzo[h]quinazoline-5,1'-cyclohexanes). Pharm Chem J 44, 405–408 (2010). https://doi.org/10.1007/s11094-010-0477-7

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  • DOI: https://doi.org/10.1007/s11094-010-0477-7

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