Abstract
A series of 2-amino-2-thiazoline derivatives have been synthesized and characterized with respect to NOS-inhibitor activity in vivo. It was established that the dimensions of the substituents in 2-N-mono-and 2-N,N-disubstituted 2-amino-2-thiazolines are not significant for the biological activity of the products.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
D. R. Janero, Free Radical Biol. Med., 28, 1495–1506 (2000).
L. Salerno, V. Sorrenti, C. Di Giacomo, et al, Curr. Pharm. Des., 8, 177–200 (2002).
S. Ya. Proskuryakov, A. G. Konoplyannikov, A. I. Ivannikov, et al., Usp. Sovrem. Biol., 119, 380–395 (1999).
M. N. Muscara and J. L. Wallace, Am. J. Physiol.: Gastrointest. Liver Physiol., 39, 1313–1316 (1999).
A. J. Hobbs, A. Higgs, and S. Moncada, Annu. Rev. Pharmacol. Toxicol., 39, 191–220 (1999).
S. Ya. Proskuryakov, N. G. Kucherenko, A. I. Trishkina, et al., Byull. Eksp. Biol. Med., 134, 393–396 (2002).
S. Ya. Proskuryakov, N. G. Kucherenko, A. A. Mandrugin, et al., Radiats. Biol. Radioekol., 43, 57–61 (2003).
T. W. Sawyer, Toxicol. Appl. Pharmacol., 155, 169–176 (1999).
S. Ya. Proskuryakov, A. G. Konoplyannikov, V. G. Skvortsov, et al., Biokhimiya, 70(1), 14–32 (2005).
S. Ya. Proskuryakov, A. G. Konoplyannikov, V. G. Skvortsov, et al., Usp. Khim., 74(9), 939–952 (2005).
M. M. Konstantinova, A. A. Mandrugin, A. G. Tarasenko, et al., Radiobiologiya, 17, 101–107 (1977).
L. G. Toldi, Khim. Geterotsikl. Soedin., 7, 878–888 (1978).
A. N. Proshin, Author's Abstract of a Candidate Dissertation in Chemical Sciences [in Russian], Moscow (2004).
T. P. Trofimova, A. N. Pushin, A. N. Proshin, et al., Khim. Geterotsikl. Soedin., 3, 456–463 (2007).
A. F. Vanin, A. Huisman, E. S.G. Stroes, et al., Free Radical Biol. Med., 30(8), 813–824 (2001).
A. F. Vanin, P. I. Mordvincev, and A. L. Kleschev, Studia Biophys., 102(2), 135–143 (1984).
L. N. Kubrina, W. S. Caldwell, P. I. Mordvintcev, et al., Biochem. Biophys. Acta, 1099, 233–237 (1992).
L. N. Kubrina, P. I. Mordvintcev, A. F. Vanin, et al., Byull. Eksp. Biol. Med., 1, 31–33 (1989).
P. Mordvintcev, A. Mulsch, A. Vanin, et al., Anal. Biochem., 199, 142–146 (1991).
A. G. Konoplyannikov, S. Ya. Proskuryakov, L. V. Steyn, et al., Bull. Exp. Biol. Med., 127(6), 648–650 (1999).
N. Sennequier, D. Wolan, D. J. Stuehr, et al., J. Biol. Chem., 274(2), 930–938 (1999).
K. McMillan, M. Adler, D. S. Auld, et al., Proc. Natl. Acad. Sci. USA, 97(4), 1506–1511 (2000).
Author information
Authors and Affiliations
Additional information
__________
Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 41, No. 12, pp. 18–20, December, 2007.
Rights and permissions
About this article
Cite this article
Mandrugin, A.A., Trofimova, T.P., Fedoseev, V.M. et al. Nitric oxide inhibitor activity of 2-amino-2-thiazoline derivatives. Pharm Chem J 41, 640–642 (2007). https://doi.org/10.1007/s11094-008-0029-6
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s11094-008-0029-6