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Principles of magnetohydrodynamic thermochemotherapy of malignant tumors (A review)

  • Molecular-Biological Problems of Drug Design and Mechanism of Drug Action
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Pharmaceutical Chemistry Journal Aims and scope

Abstract

New experimental and clinical data on the hyperthermia of malignant tumors are reviewed. The molecular biology mechanisms and principles of the magnetohydrodynamic thermochemotherapy (MHTCT) of tumors are considered. Attempts at automation of the MHTCT process using magnetically driven antitumor nanopreparations with low Curie temperatures are discussed.

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References

  1. N. A. Brusentsov, Zh. Vses. Khim. o-va im. D. I. Mendeleeva, 32(5), 562–569 (1987).

    CAS  Google Scholar 

  2. N. A. Brusentsov and V. V. Lykov, Zh. Vses. Khim. o-va im. D. I. Mendeleeva, 34(5), 566–572 (1989).

    CAS  Google Scholar 

  3. N. A. Brusentsov, Zh. Vses. Khim. o-va im. D. I. Mendeleeva, 35(6), 759–766 (1990).

    Google Scholar 

  4. P. Wust, J. Nadobny, and R. Felix, in: Medical Radiology, Principles and Practice of Thermoradiotherapy and Thermochemotherapy, M. H. Seegenschmiedt, P. Fessenden, and C. C. Vernon (eds.), Springer, Berlin (1995), pp. 219–251.

    Google Scholar 

  5. A. W. T. Konings, in: Thermoradiotherapy and Thermochemotherapy: Biology, Physiology, Physics, M. H. Seegenschmiedt, P. Fessenden, and C. C. Vernon (eds.), Springer, Berlin (1995), Vol. 1, pp. 89–102.

    Google Scholar 

  6. N. A. Brusentsov, T. N. Brusentsova, A. Yu. Baryshnikov, et al., in: Biocatalytic Technology and Nanotechnology, G. E. Zaikov (ed.), Nova Science Publishers (2004), pp. 59–63.

  7. N. A. Brusentsov, A. Yu. Baryshnikov, P. K. Ivanov, et al., RF Patent No. 2203111, Byul. Izobret., No. 12 (2003).

  8. N. A. Brusentsov, A. A. Shevelev, T. N. Brusentsova, et al., RF Patent No. 22211713, Byul. Izobret., No. 25 (2003).

  9. N. A. Brusentsov, Khim.-Farm. Zh., 30(9), 3–11 (1996).

    CAS  Google Scholar 

  10. N. A. Brusentsov, A. A. Shevelev, T. N. Brusentsova, et al., Khim.-Farm. Zh., 36(3), 8–10 (2002).

    Google Scholar 

  11. N. A. Brusentsov, L. I. Shumakov, and T. N. Brusentsova, Proceeding of the 1st Symp. “Application of Biomagnetic Carriers in Medicine,” Emmanuel Inst. Biochem. Phys., Moscow (2002), pp. 50–60.

    Google Scholar 

  12. N. A. Brusentsov, L. V. Nikitin, T. N. Brusentsova, et al., J. Magn. Magn. Mater., 252(3), 378–380 (2002).

    Article  CAS  Google Scholar 

  13. N. A. Brusentsov, T. N. Brusentsova, and E. Yu. Filinova, J. Magn. Magn. Mater., 253(1), 450–454 (2005).

    Article  Google Scholar 

  14. T. N. Brusentsova, N. A. Brusentsov, V. D. Kuznetsov, et al., J. Magn. Magn. Mater., 253(1), 298–302 (2005).

    Article  Google Scholar 

  15. F. S. Baiburtskii, L. A. Goncharov, D. B. Korman, et al., Abstracts of Papers. Int. Symp. on Magnetism, Moscow (2005), p. 126.

  16. N. A. Brusentsov, V. N. Nikiforov, T. N. Brusentsova, et al., Abstracts of Papers. Int. Symp. on Magnetism, Moscow (2005), pp. 645, 646.

  17. N. A. Brusentsov, T. N. Brusentsova, E. Yu. Filinova, et al., Abstracts of Papers. Int. Symp. on Magnetism, Moscow (2005), pp. 141, 142.

  18. N. A. Brusentsov, T. N. Brusentsova, A. V. Sergeev, et al., Khim.-Farm. Zh., 34(4), 38–44 (2000).

    Google Scholar 

  19. Y. Masuko, K. Tazawa, E. Viroonchatapan, et al., Biol. Pharmacol. Bull., 18, 1802–1804 (1995).

    CAS  Google Scholar 

  20. M. Mitsumori, M. Hiraoka, T. Shibata, et al., Int. J. Hypertherm., 10, 785–793, (1994).

    Article  CAS  Google Scholar 

  21. T. N. Brusentsova, V. A. Polyanskii, V. D. Kuznetsov, et al., Proceedings of the 11th Int. Conf. on Magnetic Fluids, Ples (2004), pp. 239–241.

  22. N. A. Brusentsov, Zh. Vses. Khim. o-va im. D. I. Mendeleeva, 36(3), 353–355 (1991).

    CAS  Google Scholar 

  23. N. A Brusentsov, M. N. Preobrazhenskaya, A. V. Ivanov, et al., USSR Inventor's Certificate No. 946546; Byul. Izobret. No 28 (1982).

  24. N. A. Brusentsov, T. N. Brusentsova, A. Yu. Baryshnikov, et al., Proceedings of the 11th Int. Conf. on Magnetic Fluids, Ples (2004), pp. 242–247.

  25. N. A. Brusentsov, T. Yu. Glazkova, N. P. Yavorskaya, et al., Eksp. Onkol., 12(6), 59–60 (1990).

    PubMed  CAS  Google Scholar 

  26. N. A. Brusentsov, M. V. Lukashevich, and V. V. Gogosov, Magn. Gidrodinam., 30(2), 215–218 (1994).

    Google Scholar 

  27. N. A. Brusentsov, V. V. Gogosov, and M. V. Lukashevich, Khim.-Farm. Zh., 30(10), 48–53 (1996).

    CAS  Google Scholar 

  28. A. A. Kuznetsov, V. A. Brukvin., N. A. Brusentsov, et al., Program and Abstracts of the 5th Int. Conf. on Scientific and Clinical Applications of Magnetic Carriers, Lyon, France (2004), p. 49.

  29. N. A. Brusentsov and T. N. Brusentsova, Khim.-Farm. Zh., 35(6), 6–11 (2001).

    Google Scholar 

  30. N. A. Brusentsov, F. S. Baiburtskii, V. V. Tarasov, et al., Khim.-Farm. Zh., 36(4), 32–40 (2002).

    Google Scholar 

  31. N. A. Brusentsov and T. N. Brusentsova, Vestn. Onkol. Nauch. Tsentra im. N. N. Blokhina Ross. Akad. Med. Nauk, No. 4, 44–56 (2002).

  32. N. A. Brusentsov, O. S. Burova, A. Yu. Baryshnikov, et al., Proceeding of the 1st Symp. “Application of Biomagnetic Carriers in Medicine,” Emmanuel Inst. Biochem. Phys., Moscow (2002), pp. 60–67.

    Google Scholar 

  33. N. A. Brusentsov, L. Kh. Komissarova, T. N. Brusentsova, et al., Khim.-Farm. Zh., 37(6), 10–15 (2003).

    Google Scholar 

  34. E. R. Vol'ter and N. A. Brusentsov, Proceeding of the 1st Symp. “Application of Biomagnetic Carriers in Medicine,” Emmanuel Inst. Biochem. Phys., Moscow (2002), pp. 94–103.

    Google Scholar 

  35. N. A. Brusentsov, V. A. Polyanskii, and T. N. Brusentsova, RF Patent No. 2236688; Byul. Izobret., No. 26 (2004).

  36. N. N. Trapeznikov and V. V. Yavorskii, in: Regional Chemotherapy of Malignant Tumors [in Russian], G. E. Ostroverkhov and N. N. Trapeznikov (eds.), Meditsina, Moscow (1967).

    Google Scholar 

  37. E. A. Luk'yanets, Zh. Vses. Khim. o-va im. D. I Mendeleeva, 43(5) 9–16 (1998).

    Google Scholar 

  38. A. V. Suvernev, A. A. Pisarev, A. N. Penyagin, et al., RF Patent No. 2126667; Byul. Izobret., No. 6 (1999).

  39. A. I. Autenshlyus, N. A. Brusentsov, and A. Lockshin, J. Magn. Magn. Mater., 122, 360–363 (1993).

    Article  CAS  Google Scholar 

  40. F. S. Baiburtskiy, M. Yu. Larin, L. A. Goncharov, et al., Program and Abstracts of the 5th Int. Conf. on the Scientific and Clinical Applications of Magnetic Carriers, Lyon, France (2004), p. 163.

  41. N. A. Brusentsov, T. S. Gendler, E. A. Haliulina, et al., Proceedings of the 9th Int. Conf. on Magnetic Fluids, Ples (2000), pp. 77–79.

  42. N. A. Brusentsov, V. V. Gogosov, T. N. Brusentsova, et al., J. Magn. Magn. Mater., 225(1–3), 113–117 (2001).

    Article  CAS  Google Scholar 

  43. N. A. Brusentsov, E. Yu. Filinova, T. N. Brusentsova, et al., Magnetohydrodynamics, 38(4), 399–408 (2002).

    Google Scholar 

  44. N. A. Brusentsov, T. N. Brusentsova, V. V. Gogosov, et al., Abstracts of Papers. Moscow Int. Symp. on Magnetism, Moscow State University, Moscow (2002), pp. 279–280.

    Google Scholar 

  45. N. A. Brusentsov, L. Kh. Komissarova, A. A. Kuznetsov, et al., Proceedings of the 4th Int. Conf. on the Scientific and Clinical Applications of Magnetic Carriers, Tallahassee, Florida, USA (2002), pp. 81–84.

  46. N. F. Tarasov, G. E. Kodina, and V. N. Korsunskii, Itogi Nauki Tekhn., Ser. Radiat. Biol., No. 10, 5–90 (1991).

  47. N. A. Brusentsov, L. Kh. Komissarova, A. A. Kuznetsov, et al., Eur. J. Cells Mater., 3(Supl. 2), 70–73 (2002).

    Google Scholar 

  48. N. A. Brusentsov, A. V. Reshetnickov, E. Yu. Filinova, et al., Workshop on Recent Advances in Nanotechnology of Magnetic Fluids (RANMF-2003), New Delhi, India (2003), pp. 182–185.

  49. Y. S. Ryabukhin, Strahlentherapie, 160, 678–680 (1984).

    PubMed  Google Scholar 

  50. G. Kong, R. D. Braun, and M. W. Dewhirst, Cancer Res., 60, 4440–4445 (2000).

    PubMed  CAS  Google Scholar 

  51. N. A. Brusentsov, V. D. Kuznetsov, T. N. Brusentsova, et al., J. Magn. Magn. Mater., 252, 2350–2351 (2004).

    Article  Google Scholar 

  52. P. Burgman, A. Nussenzweig, and G. C. Li, “Thermotolerance”, in: Thermoradiotherapy and Thermochemotherapy: Biology, Physiology, Physics, M. H. Seegenschmiedt, P. Fessenden, and C. C. Vernon (eds.), Springer, Berlin (1995), Vol. 1, pp. 75–87.

    Google Scholar 

  53. J. J. Fairbairn, M. W. Khan, K. J. Ward, et al., Cancer Lett., 89, 183–188 (1995).

    Article  PubMed  CAS  Google Scholar 

  54. P. C. Fannin and S. W. Charles, J. Physics D: Appl. Phys., 24, 76–77 (1991).

    Article  CAS  Google Scholar 

  55. J. Geshev, O. Popov, V. Masheva, et al., J. Magn. Magn. Mater., 92, 185–190 (1990).

    Article  Google Scholar 

  56. R. K. Gilchrist, R. Medal, W. D. Shorey, et al., Ann. Surg., 146, 596–606 (1957).

    Article  PubMed  CAS  Google Scholar 

  57. R. K. Gilchrist, W. D. Shorey, R. C. Hanselman, et al., Ann. Surg., 161, 890–896 (1965).

    Article  PubMed  CAS  Google Scholar 

  58. E. R. Vol'ter, N. A. Brusentsov, and V. A. Polyanskii, Proceedings of the 11th Int. Conf. on Magnetic Fluids, Ples (2004), pp. 234–238.

  59. P. Tartaj, M. P. Morales, and S. V. Verdaguer, J. Phys. D: Appl. Phys., 36, 182–197 (2003).

    Article  Google Scholar 

  60. R. T., Gordon, J. R. Hines, and D. Gordon, Med. Hypothesis, 5, 83–102 (1979).

    Article  CAS  Google Scholar 

  61. M. Hanson, J. Magn. Magn. Mater., 96, 105–113 (1991).

    Article  CAS  Google Scholar 

  62. B. V. Harmon, Y. S. Takano, C. M. Winterford, et al., Int. J. Radiat. Biol., 59, 489–501 (1991).

    Article  PubMed  CAS  Google Scholar 

  63. R. Hiergeist, W. Andrä, N. Buske, et al., J. Magn. Magn. Mater., 201, 420–422 (1999).

    Article  CAS  Google Scholar 

  64. A. Jordan, R. Scholz, K. Maier-Hauff, et al., J. Magn. Magn. Mater., 225, 118–126 (2001).

    Article  CAS  Google Scholar 

  65. A. Jordan, P. Wust, H. Fahling, et al., Int. J. Hypertherm., 9, 51–68 (1993).

    Article  CAS  Google Scholar 

  66. A. Jordan, P. Wust, R. Scholz, et al., Int. J. Hypertherm., 12, 705–722 (1996).

    Article  CAS  Google Scholar 

  67. A. Jordan, Der Onkol., 7, 1073–1081 (2001).

    Article  Google Scholar 

  68. A. Jordan et al., in: Magnetic Fluid Hyperthermia (MFH): Scientific and Clinical Applications of Magnetic Carriers, U. Hafeli et al. (ed.), Plenum Press, New York (1997).

    Google Scholar 

  69. A. Jordan, R. Scholz, P. Wust, et al., J. Magn. Magn. Mater., 194, 185–196 (1999).

    Article  CAS  Google Scholar 

  70. O. A. Kuznetsov, N. A. Brusentsov, A. A. Kuznetsov, et al., J. Magn. Magn. Mater., 194, 83–89 (1999).

    Article  CAS  Google Scholar 

  71. A. A. Kuznetsov, O. A. Shlyakhtin, N. A. Brusentsov, et al., Eur. J. Cells Mater., 3(Supl. 2), 75–77 (2002).

    Google Scholar 

  72. C. Alexiou, W. Arnold, R. J. Klein, et al., Cancer Res., 60, 6641–6648 (2000).

    PubMed  CAS  Google Scholar 

  73. I. A. Lerch and D. J. Pizzarrello, Med. Phys., 13, 786 (1986).

    Google Scholar 

  74. I. A. Lerch, Radiation Research, Proceedings of the 8th Int. Congr. on Radiation Research, Edinburgh (1987), p. 325.

  75. A. Luderer, N. F. Borrelli, J. N. Panzarino, et al., Radiat. Res., 94, 190–198 (1983).

    Article  PubMed  CAS  Google Scholar 

  76. B. S. Medal, W. Shorey, R. K. Gilchrist, et al., A. M. A. Arch. Surg., 79, 427–431 (1959).

    Google Scholar 

  77. G. Multhoff, C. Botzler, M. Wiesnet, et al., Int. J. Cancer, 61, 272–279 (1995).

    Article  PubMed  CAS  Google Scholar 

  78. R. W. Rand, H. D. Snow, and W. J. Brown, J. Surg. Res., 33, 177–183 (1982).

    Article  PubMed  CAS  Google Scholar 

  79. K. S. Sellins and J. J. Cohen, Radiat. Res., 126, 88–95 (1991).

    Article  PubMed  CAS  Google Scholar 

  80. M. I. Shliomis, A. F. Pshenichnikov, K. I. Morozov, et al., J. Magn. Magn. Mater., 85, 40–46 (1990).

    Article  CAS  Google Scholar 

  81. P. K. Sneed, P. R. Stauffer, C. J. Diederich, et al., Int. J. Radiat. Oncol. Biol. Phys., Proceedings of the 38th Meeting of the American Society for Therapeutic Radiology and Oncology, 36(Suppl. 1), 159 (1996).

    Article  Google Scholar 

  82. C. W. Song, I. B. Choi, B. S. Nah, et al., in: Thermoradiotherapy and Thermochemotherapy: Biology, Physiology, Physics, M. H. Seegenschmiedt, P. Fessenden, and C. C. Vernon (eds.), Springer, Berlin (1995), Vol. 1, pp. 139–156.

    Google Scholar 

  83. C. Streffer and D. van Beuningen, The Biological Basis for Tumor Therapy by Hyperthermia and Radiation, in: Hyperthermia and the Therapy of Malignant Tumors, J. Streffer (ed.), Springer, Berlin (1987), pp. 24–70.

    Google Scholar 

  84. Y. S. Takano, B. V. Harmon, and J. F. R. Kerr, J. Pathol., 163, 329–336 (1991).

    Article  PubMed  CAS  Google Scholar 

  85. R. Valdagni and M. Amichetti, Int. J. Radiat. Oncol. Biol. Phys., 28, 163–169 (1993).

    Google Scholar 

  86. C. C. Vernon, J. W. Hand, S. B. Field, et al., Int. J. Radiat. Oncol. Biol. Phys., 35, 731–744 (1996).

    PubMed  CAS  Google Scholar 

  87. J. K. Watson, Applications of Magnetism, Wiley, New York (1980), pp. 6–7.

    Google Scholar 

  88. P. Wust, H. Stahl, J. Loffel, et al., Int. J. Hypertherm., 11, 151–167 (1995).

    Article  CAS  Google Scholar 

  89. M. Chistofalli, C. Charnsangavej, and G. N. Hortobagyi, Nature Rev., 1, 415–426 (2002).

    Article  Google Scholar 

  90. L. M. Ellis, Horizons Cancer Res., 3(1), 4–22 (2002).

    Google Scholar 

  91. D. Hanahan and J. Folkman, Cell, 86, 353–364 (1996).

    Article  PubMed  CAS  Google Scholar 

  92. R. Kerbel and J. Folkman, Nature Rev., 2, 727–739 (2002).

    Article  CAS  Google Scholar 

  93. N. N. Blokhin, N. N. Trapeznikov, V. V. Yavorskii, State of the Art in the Regional Chemotherapy of Malignant Tumors by Means of Perfusion, in: Regional Chemotherapy of Malignant Tumors [in Russian], G. E. Ostroverkhov and N. N. Trapeznikov (eds.), Meditsina, (1967).

  94. E. V. Stepanova, Prakt. Onkol., No. 4, 246–252 (2002).

  95. A. Yu. Baryshnikov, E. V. Stepanova, and M. R. Lichinitser, Usp. Sovrem. Biol., 120(6), 599–604 (2000).

    Google Scholar 

  96. E. V. Tselishcheva, Zh. N. Dbar, and E. V. Stepanova, Usp. Sovrem. Biol., 124(5), 480–488 (2004).

    Google Scholar 

  97. M. V. Moiseenko, I. A. Baldueva, L. A. Shchekina, et al., Ross. Bioter. Zh., 4(3), 122–130 (2005).

    Google Scholar 

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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 41, No. 9, pp. 3–8, September, 2007.

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Brusentsov, N.A., Brusentsova, T.N. & Filinova, E.Y. Principles of magnetohydrodynamic thermochemotherapy of malignant tumors (A review). Pharm Chem J 41, 455–460 (2007). https://doi.org/10.1007/s11094-007-0099-x

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