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Pharmacological activity and clinical effects of trecrezan and other tris-(2-hydroxyethyl)ammonium salts of arylheteroacetic acids (A review)

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Abstract

The results of an experimental and clinical study on the pharmacological properties of new compounds representing tris-(2-hydroxyethyl)ammonium salts (TES) of arylheteroacetic acids-in particular, tris-(2-hydroxyethyl)ammonium-2-methylphenoxyacetate (trecrezan)-are summarized. Trecrezan exhibits a modulating action on immunity and hemopoiesis and offers a promising approach to immune correction for the treatment of immune deficiency and autoimmune disorders. Recovery of the proliferative activity of the early precursors of erythropoiesis with the aid of trecrezan (experimental model) leads to the normalization of immunity and hemopoiesis. A method involving trecrezan administration has been developed for the complex treatment of acute viral hepatitis B as well as hepatitis A and B complicated by occupational anamnesis. Trecrezan has also been successfully applied for the complex treatment of ischemic heart disease and multiple sclerosis. Trecrezan stimulates the regeneration of hepatocytes during partial hepatectomy and acts as an effective adjuvant in the complex therapy of tuberculosis. Trecrezan analogs (TES) show antitumor, hepatoprotective, and adaptive activity, increase the resistance of animals to oxygen insufficiency and to poisoning with heavy metal salts and organophosphorus compounds, and improve the endurance of animals under physical load and emotional stress conditions.

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Authors and Affiliations

  1. Favorsky Institute of Chemistry, Siberian Division, Russian Academy of Science, Irkutsk, Russia

    M. G. Voronkov, M. M. Rasulov & A. N. Mirskova

  2. Institute of Clinical Immunology, Siberian Division, Russian Academy of Medical Sciences, Novosibirsk, Russia

    O. P. Kolesnikova

Authors
  1. M. G. Voronkov
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  2. O. P. Kolesnikova
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  3. M. M. Rasulov
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  4. A. N. Mirskova
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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 41, No. 5, pp. 13–17, May, 2007.

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Voronkov, M.G., Kolesnikova, O.P., Rasulov, M.M. et al. Pharmacological activity and clinical effects of trecrezan and other tris-(2-hydroxyethyl)ammonium salts of arylheteroacetic acids (A review). Pharm Chem J 41, 244–248 (2007). https://doi.org/10.1007/s11094-007-0054-x

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  • DOI: https://doi.org/10.1007/s11094-007-0054-x

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