Abstract
Antipyrine and its benzenesulfonate were iodinated by solid-state mechanical activation (in the absence of solvent) under the action of iodine, iodine chloride, Me4N+ICl2 −, and Et4N+ICl2 − with the formation of 4-iodoantipyrine. The proposed process does not require organic solvents and meets all Green Chemistry demands. The best results were achieved with the use of tetraalkylammonium salts Me4N+ICl2 − and Et4N+ICl2 −.
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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 41, No. 3, pp. 35–36, March, 2007.
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Krasnokutskaya, E.A., Trusova, M.E., Gibert, N.S. et al. 4-Iodoantipyrine synthesized by means of solid-state mechanical activation. Pharm Chem J 41, 154–156 (2007). https://doi.org/10.1007/s11094-007-0034-1
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DOI: https://doi.org/10.1007/s11094-007-0034-1